(E)-tert-butyl methyl(4-(4-(prop-2-yn-1-yloxy)styryl)phenyl)carbamate

Base Information

Chemical Name:(E)-tert-butyl methyl(4-(4-(prop-2-yn-1-yloxy)styryl)phenyl)carbamate
CAS No.:1422568-49-7
Molecular Formula:C₂₃H₂₅NO₃
Molecular Weight:363.456
Hs Code.:

Synonyms:(E)-tert-butyl methyl(4-(4-(prop-2-yn-1-yloxy)styryl)phenyl)carbamate

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Chemical Property of (E)-tert-butyl methyl(4-(4-(prop-2-yn-1-yloxy)styryl)phenyl)carbamate

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Technology Process of (E)-tert-butyl methyl(4-(4-(prop-2-yn-1-yloxy)styryl)phenyl)carbamate

There total 7 articles about (E)-tert-butyl methyl(4-(4-(prop-2-yn-1-yloxy)styryl)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: tert-butyl (4-((diethoxyphosphoryl)methyl)phenyl)(methyl)carbamate

: 5651-86-5
4-(prop-2-ynyloxy)benzaldehyde

: 1422568-49-7
(E)-tert-butyl methyl(4-(4-(prop-2-yn-1-yloxy)styryl)phenyl)carbamate

Guidance literature:: tert-butyl (4-((diethoxyphosphoryl)methyl)phenyl)(methyl)carbamate; With sodium hydride; In N,N-dimethyl-formamide; for 1h; Inert atmosphere;

4-(prop-2-ynyloxy)benzaldehyde; In N,N-dimethyl-formamide; for 12h; Inert atmosphere;
DOI:10.1021/jm301435z

Reference yield:

: 1349698-20-9
tert-butyl (4-((diethoxyphosphoryl)methyl)phenyl)(methyl)carbamate

: 5651-86-5
4-(prop-2-ynyloxy)benzaldehyde

: 1422568-49-7
(E)-tert-butyl methyl(4-(4-(prop-2-yn-1-yloxy)styryl)phenyl)carbamate

Guidance literature:: tert-butyl (4-((diethoxyphosphoryl)methyl)phenyl)(methyl)carbamate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

4-(prop-2-ynyloxy)benzaldehyde; In N,N-dimethyl-formamide; at 0 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b01328

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1422568-49-7
(E)-tert-butyl methyl(4-(4-(prop-2-yn-1-yloxy)styryl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; tetrahydrofuran / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / Inert atmosphere

3.2: 12 h / Inert atmosphere

With sodium hydride; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil; 3.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jm301435z