N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide

Base Information

Chemical Name:N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide
CAS No.:1396772-45-4
Molecular Formula:C₃₀H₃₅N₅O₃
Molecular Weight:513.64
Hs Code.:

Synonyms:N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide

Chemical Property:

Purity/Quality:: ≥95% ^*data from raw suppliers

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Technology Process of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide

There total 10 articles about N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.7%

: 1346702-51-9
6-bromo-N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-1-(1-methylethyl)-1H-indazole-4-carboxamide

: 364794-79-6
4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]morpholine

: 1396772-45-4
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide

Guidance literature:: 6-bromo-N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-1-(1-methylethyl)-1H-indazole-4-carboxamide; 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; for 0.166667h; Inert atmosphere;

With sodium carbonate; In 1,4-dioxane; at 100 ℃; for 2.16667h; Inert atmosphere;

Reference yield:

: 107650-20-4
5-bromo-2-methyl-3-nitro-benzoic acid

: 1396772-45-4
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

3.1: potassium acetate / chloroform / 12 h / 20 °C

3.2: 3 h / 65 °C

4.1: hydrogenchloride / water; methanol / 8 h / 60 °C

4.2: pH 8

5.1: caesium carbonate / acetonitrile / 2 h / 90 °C

6.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

7.1: dimethyl sulfoxide / 0.25 h / 20 °C

8.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.17 h / Inert atmosphere

8.2: 2.17 h / 100 °C / Inert atmosphere

With hydrogenchloride; water; potassium acetate; iron; sodium carbonate; ammonium chloride; caesium carbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; ethanol; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; 8.1: Suzuki Coupling;

Reference yield:

: 220514-28-3
5-bromo-2-methyl-3-nitrobenzoic acid methyl ester

: 1396772-45-4
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

2.1: potassium acetate / chloroform / 12 h / 20 °C

2.2: 3 h / 65 °C

3.1: hydrogenchloride / water; methanol / 8 h / 60 °C

3.2: pH 8

4.1: caesium carbonate / acetonitrile / 2 h / 90 °C

5.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

6.1: dimethyl sulfoxide / 0.25 h / 20 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.17 h / Inert atmosphere

7.2: 2.17 h / 100 °C / Inert atmosphere

With hydrogenchloride; water; potassium acetate; iron; ammonium chloride; caesium carbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; ethanol; chloroform; water; dimethyl sulfoxide; acetonitrile; 7.1: Suzuki Coupling;