3-Cyano-4-{[3'-methoxy-3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}-N-(1,3-thiazol-2-yl)benzenesulfonamide

Base Information

Chemical Name:3-Cyano-4-{[3'-methoxy-3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}-N-(1,3-thiazol-2-yl)benzenesulfonamide
CAS No.:1354786-24-5
Molecular Formula:C₂₇H₂₁N₅O₄S₂
Molecular Weight:543.627
Hs Code.:

Synonyms:3-Cyano-4-{[3'-methoxy-3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}-N-(1,3-thiazol-2-yl)benzenesulfonamide

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Chemical Property of 3-Cyano-4-{[3'-methoxy-3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}-N-(1,3-thiazol-2-yl)benzenesulfonamide

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Technology Process of 3-Cyano-4-{[3'-methoxy-3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}-N-(1,3-thiazol-2-yl)benzenesulfonamide

There total 5 articles about 3-Cyano-4-{[3'-methoxy-3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}-N-(1,3-thiazol-2-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1354787-24-8
4-[4-bromo-2-(2-methyl-2H-pyrazol-3-yl)-phenoxy]-3-cyano-N-(2,4-dimethoxy-benzyl)-N-thiazol-2-yl-benzenesulfonamide

: 10365-98-7,1107579-37-2
3-methoxyphenylboronic acid

: 1354786-24-5
3-Cyano-4-{[3'-methoxy-3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}-N-(1,3-thiazol-2-yl)benzenesulfonamide

Guidance literature:: 4-[4-bromo-2-(2-methyl-2H-pyrazol-3-yl)-phenoxy]-3-cyano-N-(2,4-dimethoxy-benzyl)-N-thiazol-2-yl-benzenesulfonamide; 3-methoxyphenylboronic acid; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; for 4.5h; Inert atmosphere; Reflux;

With trifluoroacetic acid; In dichloromethane; for 1h;

Reference yield:

: 351003-23-1
3-cyano-4-fluorobenzene-1-sulfonyl chloride

: 1354786-24-5
3-Cyano-4-{[3'-methoxy-3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}-N-(1,3-thiazol-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -50 - 20 °C

1.2: 0.5 h / -78 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

2.2: 3 h

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 4.5 h / Inert atmosphere; Reflux

3.2: 1 h

With sodium hydride; potassium carbonate; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil; 3.1: Suzuki Coupling;

Reference yield:

: 1354787-25-9
4-bromo-2-(1-methyl-1H-pyrazol-5-yl)phenol

: 1354786-24-5
3-Cyano-4-{[3'-methoxy-3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}-N-(1,3-thiazol-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

1.2: 3 h

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 4.5 h / Inert atmosphere; Reflux

2.2: 1 h

With sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene; mineral oil; 2.1: Suzuki Coupling;