4-[4-bromo-2-(2-methyl-2H-pyrazol-3-yl)-phenoxy]-3-cyano-N-(2,4-dimethoxy-benzyl)-N-thiazol-2-yl-benzenesulfonamide

Base Information

Chemical Name:4-[4-bromo-2-(2-methyl-2H-pyrazol-3-yl)-phenoxy]-3-cyano-N-(2,4-dimethoxy-benzyl)-N-thiazol-2-yl-benzenesulfonamide
CAS No.:1354787-24-8
Molecular Formula:C₂₉H₂₄BrN₅O₅S₂
Molecular Weight:666.576
Hs Code.:

Synonyms:4-[4-bromo-2-(2-methyl-2H-pyrazol-3-yl)-phenoxy]-3-cyano-N-(2,4-dimethoxy-benzyl)-N-thiazol-2-yl-benzenesulfonamide

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Chemical Property of 4-[4-bromo-2-(2-methyl-2H-pyrazol-3-yl)-phenoxy]-3-cyano-N-(2,4-dimethoxy-benzyl)-N-thiazol-2-yl-benzenesulfonamide

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Technology Process of 4-[4-bromo-2-(2-methyl-2H-pyrazol-3-yl)-phenoxy]-3-cyano-N-(2,4-dimethoxy-benzyl)-N-thiazol-2-yl-benzenesulfonamide

There total 4 articles about 4-[4-bromo-2-(2-methyl-2H-pyrazol-3-yl)-phenoxy]-3-cyano-N-(2,4-dimethoxy-benzyl)-N-thiazol-2-yl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1354787-25-9
4-bromo-2-(1-methyl-1H-pyrazol-5-yl)phenol

: 1354787-26-0
3-cyano-N-(2,4-dimethoxybenzyl)-4-fluoro-N-(thiazol-2-yl)benzene sulfonamide

: 1354787-24-8
4-[4-bromo-2-(2-methyl-2H-pyrazol-3-yl)-phenoxy]-3-cyano-N-(2,4-dimethoxy-benzyl)-N-thiazol-2-yl-benzenesulfonamide

Guidance literature:: 4-bromo-2-(1-methyl-1H-pyrazol-5-yl)phenol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.5h;

3-cyano-N-(2,4-dimethoxybenzyl)-4-fluoro-N-(thiazol-2-yl)benzene sulfonamide; In N,N-dimethyl-formamide; mineral oil; for 3h;

Reference yield:

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 1354787-24-8
4-[4-bromo-2-(2-methyl-2H-pyrazol-3-yl)-phenoxy]-3-cyano-N-(2,4-dimethoxy-benzyl)-N-thiazol-2-yl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: piperidine / 1,1-dichloroethane / 18 h / Reflux; Molecular sieve

1.2: 2 h / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -50 - 20 °C

2.2: 0.5 h / -78 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

3.2: 3 h

With piperidine; sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; 1,1-dichloroethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 51483-92-2
6-bromo-1-benzopyran-4(4H)-one

: 1354787-24-8
4-[4-bromo-2-(2-methyl-2H-pyrazol-3-yl)-phenoxy]-3-cyano-N-(2,4-dimethoxy-benzyl)-N-thiazol-2-yl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol; boron trifluoride diethyl etherate / 22 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

2.2: 3 h

With ethanol; boron trifluoride diethyl etherate; sodium hydride; In N,N-dimethyl-formamide; mineral oil;