1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(4-methoxytetrahydropyran-4-yl)-β-D-arabino-pentofuranosyl>thymine

Base Information

Chemical Name:1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(4-methoxytetrahydropyran-4-yl)-β-D-arabino-pentofuranosyl>thymine
CAS No.:129678-68-8
Molecular Formula:C₃₆H₄₉N₃O₇S₂Si
Molecular Weight:728.018
Hs Code.:

1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(4-methoxytetrahydropyran-4-yl)-β-D-arabino-pentofuranosyl>thymine

Synonyms:1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(4-methoxytetrahydropyran-4-yl)-β-D-arabino-pentofuranosyl>thymine

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Chemical Property of 1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(4-methoxytetrahydropyran-4-yl)-β-D-arabino-pentofuranosyl>thymine

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Technology Process of 1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(4-methoxytetrahydropyran-4-yl)-β-D-arabino-pentofuranosyl>thymine

There total 1 articles about 1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(4-methoxytetrahydropyran-4-yl)-β-D-arabino-pentofuranosyl>thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 17327-22-9
4-methoxy-2,6-dihydropyran

: 129678-64-4
1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-β-D-arabino-pentofuranosyl>thymine

: 129678-68-8
1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(4-methoxytetrahydropyran-4-yl)-β-D-arabino-pentofuranosyl>thymine

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; Ambient temperature;
DOI:10.1021/jm00171a024

Reference yield: 93.0%

: 129678-68-8
1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(4-methoxytetrahydropyran-4-yl)-β-D-arabino-pentofuranosyl>thymine

: 129678-70-2
1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-formyl-2-O-(4-methoxytetrahydropyran-4-yl)-β-D-arabino-pentofuranosyl>thymine

Guidance literature:: With mercury salts; at 0 ℃; for 0.116667h;
DOI:10.1021/jm00171a024

Reference yield:

: 129678-68-8
1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(4-methoxytetrahydropyran-4-yl)-β-D-arabino-pentofuranosyl>thymine

: 129678-72-4
1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(difluoromethyl)-2-O-(4-methoxytetrahydropyran-4-yl)-β-D-arabino-pentofuranosyl>thymine

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / mercury salts / 0.12 h / 0 °C

2: 82 percent / (diethylamino)sulfur trifluoride (DAST) / CH₂Cl₂ / 90 h / Ambient temperature

With diethylamino-sulfur trifluoride; mercury salts; In dichloromethane;
DOI:10.1021/jm00171a024