3-oxo-2-(4-hexadecylphenyl)-4-phenylbutanenitrile

Base Information

Chemical Name:3-oxo-2-(4-hexadecylphenyl)-4-phenylbutanenitrile
CAS No.:936574-73-1
Molecular Formula:C₃₂H₄₅NO
Molecular Weight:459.715
Hs Code.:

Synonyms:3-oxo-2-(4-hexadecylphenyl)-4-phenylbutanenitrile

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Chemical Property of 3-oxo-2-(4-hexadecylphenyl)-4-phenylbutanenitrile

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Technology Process of 3-oxo-2-(4-hexadecylphenyl)-4-phenylbutanenitrile

There total 7 articles about 3-oxo-2-(4-hexadecylphenyl)-4-phenylbutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 116526-71-7
1-(4-bromophenyl)hexadecan-1-one

: 936574-73-1
3-oxo-2-(4-hexadecylphenyl)-4-phenylbutanenitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 30 percent / triethylsilane; trifluoroacetic acid / 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 20 h / Heating

2.2: 37 percent / tetrahydrofuran / cooling

3.1: 70 percent / LiAlH₄ / tetrahydrofuran / 24 h / Heating

4.1: tetrabutylammonium fluoride / acetonitrile / 2 h

5.1: sodium ethoxide / ethanol; heptane / 20 h / Heating

With triethylsilane; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; isopropylmagnesium chloride; sodium ethanolate; trifluoroacetic acid; In tetrahydrofuran; ethanol; n-heptane; acetonitrile;
DOI:10.1021/ja067461q

Reference yield:

: 936574-71-9
(4-hexadecylphenyl)methanol

: 936574-73-1
3-oxo-2-(4-hexadecylphenyl)-4-phenylbutanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammonium fluoride / acetonitrile / 2 h

2: sodium ethoxide / ethanol; heptane / 20 h / Heating

With tetrabutyl ammonium fluoride; sodium ethanolate; In ethanol; n-heptane; acetonitrile;
DOI:10.1021/ja067461q

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 936574-73-1
3-oxo-2-(4-hexadecylphenyl)-4-phenylbutanenitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: 34 percent / AlCl₃ / 1 h / 70 °C

2.1: 30 percent / triethylsilane; trifluoroacetic acid / 20 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 20 h / Heating

3.2: 37 percent / tetrahydrofuran / cooling

4.1: 70 percent / LiAlH₄ / tetrahydrofuran / 24 h / Heating

5.1: tetrabutylammonium fluoride / acetonitrile / 2 h

6.1: sodium ethoxide / ethanol; heptane / 20 h / Heating

With triethylsilane; lithium aluminium tetrahydride; aluminium trichloride; tetrabutyl ammonium fluoride; isopropylmagnesium chloride; sodium ethanolate; trifluoroacetic acid; In tetrahydrofuran; ethanol; n-heptane; acetonitrile;
DOI:10.1021/ja067461q