Technology Process of methyl 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-morpholino-4-oxo-4H-chromene-6-carboxylate
There total 10 articles about methyl 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-morpholino-4-oxo-4H-chromene-6-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
caesium carbonate;
Palladium complex;
In
1,4-dioxane;
at 80 ℃;
for 23h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: bromine; pyridine / dichloromethane / 2 h / 0 - 20 °C
2.1: trifluoroborane diethyl ether / toluene / 20 °C / Inert atmosphere
2.2: 12 h / 90 °C
3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 7 h / 80 °C / Inert atmosphere
4.1: hydrogen / 5% rhodium on activated aluminium oxide / methanol / 7 h / 65 °C / 3750.38 Torr
5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C
6.1: caesium carbonate / Palladium complex / 1,4-dioxane / 23 h / 80 °C / Inert atmosphere
With
pyridine; hydrogenchloride; hydrogen; bromine; trifluoroborane diethyl ether; sodium carbonate; caesium carbonate;
bis-triphenylphosphine-palladium(II) chloride; 5% rhodium on activated aluminium oxide;
In
1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: triethylamine / palladium diacetate; 1,1'-bis(diphenylphosphino)ferrocene / ethanol / 70 °C / Inert atmosphere
2.1: bromine; pyridine / dichloromethane / 2 h / 0 - 20 °C
3.1: trifluoroborane diethyl ether / toluene / 20 °C / Inert atmosphere
3.2: 12 h / 90 °C
4.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 7 h / 80 °C / Inert atmosphere
5.1: hydrogen / 5% rhodium on activated aluminium oxide / methanol / 7 h / 65 °C / 3750.38 Torr
6.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C
7.1: caesium carbonate / Palladium complex / 1,4-dioxane / 23 h / 80 °C / Inert atmosphere
With
pyridine; hydrogenchloride; hydrogen; bromine; trifluoroborane diethyl ether; sodium carbonate; caesium carbonate; triethylamine;
bis-triphenylphosphine-palladium(II) chloride; 1,1'-bis(diphenylphosphino)ferrocene; 5% rhodium on activated aluminium oxide; palladium diacetate;
In
1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; toluene;
