(RS)-1-{1-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]ethyl}-3,5-bis(trifluoromethyl)benzene

Base Information

Chemical Name:(RS)-1-{1-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]ethyl}-3,5-bis(trifluoromethyl)benzene
CAS No.:374819-23-5
Molecular Formula:C₂₅H₂₆F₆O₃
Molecular Weight:488.47
Hs Code.:

Synonyms:(RS)-1-{1-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]ethyl}-3,5-bis(trifluoromethyl)benzene

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Chemical Property of (RS)-1-{1-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]ethyl}-3,5-bis(trifluoromethyl)benzene

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Technology Process of (RS)-1-{1-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]ethyl}-3,5-bis(trifluoromethyl)benzene

There total 6 articles about (RS)-1-{1-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]ethyl}-3,5-bis(trifluoromethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 374819-22-4
1-{1-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]ethenyl}-3,5-bis(trifluoromethyl)benzene

: 374819-23-5
(RS)-1-{1-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]ethyl}-3,5-bis(trifluoromethyl)benzene

Guidance literature:: With hydrogen; 5%-palladium/activated carbon; In ethanol; ethyl acetate; for 3h; under 2585.81 Torr;

Reference yield:

: 51510-00-0
(8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)methanol

: 374819-23-5
(RS)-1-{1-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]ethyl}-3,5-bis(trifluoromethyl)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 20 °C

2: toluene / 90 °C

3: H₂ / Pd/C / ethyl acetate; ethanol / 20 °C

With hydrogen; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/S0960-894X(02)00249-4

Reference yield:

: 51509-98-9
8-Phenyl-1,4-dioxaspiro<4.5>decan-8-carbonitril

: 374819-23-5
(RS)-1-{1-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]ethyl}-3,5-bis(trifluoromethyl)benzene

Guidance literature:: Multi-step reaction with 4 steps

1.1: DIBAL-H / toluene / -78 °C

1.2: NaBH₄; EtOH

2.1: CH₂Cl₂ / 20 °C

3.1: toluene / 90 °C

4.1: H₂ / Pd/C / ethyl acetate; ethanol / 20 °C

With hydrogen; diisobutylaluminium hydride; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/S0960-894X(02)00249-4