ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-chlorophenyl]sulfamoylacetate

Base Information

• Chemical Name: ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-chlorophenyl]sulfamoylacetate
• CAS No.: 337519-88-7
• Molecular Formula: C₂₀H₂₉ClN₂O₇S
• Molecular Weight: 476.978
• Mol file: 337519-88-7.mol

Synonyms:ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-chlorophenyl]sulfamoylacetate

Chemical Property of ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-chlorophenyl]sulfamoylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-chlorophenyl]sulfamoylacetate

There total 2 articles about ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-chlorophenyl]sulfamoylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-chloroaniline (337519-87-6) + ethyl 2-(chlorosulfonyl)acetate (55896-93-0) → ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-chlorophenyl]sulfamoylacetate (337519-88-7)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 5h;

Reference yield: 54.0%

4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-chloroaniline (337519-87-6) + ethyl 2-(chlorosulfonyl)acetate (55896-93-0) + ethyl acetate (141-78-6) → ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-chlorophenyl]sulfamoylacetate (337519-88-7)

Guidance literature:

With pyridine; In hexane; dichloromethane;

Reference yield: 78.0%

ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-chlorophenyl]sulfamoylacetate (337519-88-7) + 3-(3-cyanophenyl)-2-(E)-propen-1-ol (98116-50-8) → ethyl (N-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-chlorophenyl}-N-[(E)-3-(3-cyanophenyl)-2-propenyl]sulfamoyl)acetate (337521-65-0)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; at 0 - 20 ℃;

upstream raw materials:

4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-chloroaniline

ethyl 2-(chlorosulfonyl)acetate

ethyl acetate

Downstream raw materials:

ethyl (N-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-chlorophenyl}-N-[(E)-3-(3-cyanophenyl)-2-propenyl]sulfamoyl)acetate

Ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-chlorophenyl]-N-[3-(5-cyano-2-methoxymethoxyphenyl)-2-(E)-propenyl]sulfamoylacetate