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7-(4-bromo-2-fluoro-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid cyclopropyl-methoxy-amide

Base Information Edit
  • Chemical Name:7-(4-bromo-2-fluoro-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid cyclopropyl-methoxy-amide
  • CAS No.:1193487-32-9
  • Molecular Formula:C19H19BrFN3O3
  • Molecular Weight:436.281
  • Hs Code.:
  • Mol file:1193487-32-9.mol
7-(4-bromo-2-fluoro-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid cyclopropyl-methoxy-amide

Synonyms:7-(4-bromo-2-fluoro-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid cyclopropyl-methoxy-amide

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Chemical Property of 7-(4-bromo-2-fluoro-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid cyclopropyl-methoxy-amide Edit
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Technology Process of 7-(4-bromo-2-fluoro-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid cyclopropyl-methoxy-amide

There total 4 articles about 7-(4-bromo-2-fluoro-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid cyclopropyl-methoxy-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
7-(4-bromo-2-fluoro-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 0.5h;
O-cyclopropylmethyl-hydroxylamine; With triethylamine; In N,N-dimethyl-formamide; for 16h;
Guidance literature:
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 12.33 h / -78 - 20 °C
2.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 80 °C
3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C
3.2: pH 1
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h
4.2: 16 h
With water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
Guidance literature:
Multi-step reaction with 3 steps
1.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 80 °C
2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C
2.2: pH 1
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h
3.2: 16 h
With water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
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