4-IODO-2-CYANOPYRIDINE

Base Information

• Chemical Name: 4-IODO-2-CYANOPYRIDINE
• CAS No.: 913836-19-8
• Molecular Formula: C6H3IN2
• Molecular Weight: 230.008
• Hs Code.: 2933399090
• Mol file: 913836-19-8.mol

Synonyms:2-Cyano-4-iodopyridine;4-Iodopyridine-2-carbonitrile;

Chemical Property of 4-IODO-2-CYANOPYRIDINE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 67-69ºC
• Refractive Index: 1.67
• Boiling Point: 301.716 °C at 760 mmHg
• Flash Point: 136.273 °C
• PSA: 36.68000
• Density: 2.043 g/cm³
• LogP: 1.55788
• Storage Temp.: Keep Cold

Purity/Quality:

97% ^*data from raw suppliers

4-Iodo-2-pyridinecarbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-IODO-2-CYANOPYRIDINE is used for the preparation of fused heterocyclic derivatives as Smoc inhibitors for treating cancer.

Technology Process of 4-IODO-2-CYANOPYRIDINE

There total 2 articles about 4-IODO-2-CYANOPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

sodium cyanide (773837-37-9) + 2-fluoro-4-iodopyridine (22282-70-8) → 4-iodopyridine-2-carbonitrile (913836-19-8)

Guidance literature:

In dimethyl sulfoxide; at 100 ℃;

Reference yield:

4-bromo-2-cyanopyridine (62150-45-2) → 4-iodopyridine-2-carbonitrile (913836-19-8)

Guidance literature:

With copper(l) iodide; sodium iodide; N,N`-dimethylethylenediamine; In 1,4-dioxane; at 110 ℃; for 20h; Inert atmosphere;

upstream raw materials:

sodium cyanide

2-fluoro-4-iodopyridine

4-bromo-2-cyanopyridine