(1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)butyrate

Base Information

Chemical Name:(1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)butyrate
CAS No.:122778-44-3
Molecular Formula:C₂₁H₄₂O₃Si
Molecular Weight:370.648
Hs Code.:

Synonyms:(1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)butyrate

Suppliers and Price of (1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)butyrate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)butyrate

Chemical Property:

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Technology Process of (1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)butyrate

There total 3 articles about (1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 111070-64-5
(1R,3R,4S)-p-menthan-3-yl (2R)-2-hydroxymethylbutyrate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 122778-44-3
(1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)butyrate

Guidance literature:: With dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide; for 10h; Ambient temperature;

Reference yield:

: 2216-51-5
(-)-menthol

: 122778-44-3
(1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)butyrate

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / dicyclohexylcarbodi-imide, 4-(N,N-dimethylamino)pyridine / acetonitrile; CH₂Cl₂ / -40 deg C, 6 h; room temperature, 10 h; oily substance was set aside for 5 days at room temperature

2: 1.) oxalyl chloride, 2.) tetrabutylammonium borohydride / 1.) CH₂Cl₂, reflux, 2 h, 2.) -78 deg C, 30 min

3: 91 percent / 4-(N,N-dimethylamino)pyridine, triethylamine / CH₂Cl₂; dimethylformamide / 10 h / Ambient temperature

With dmap; oxalyl dichloride; tetrabutylammonium borohydride; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 111042-75-2
(1R,3R,4S)-p-menthan-3-yl hydrogen (R)-ethylmalonate

: 122778-44-3
(1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)butyrate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) oxalyl chloride, 2.) tetrabutylammonium borohydride / 1.) CH₂Cl₂, reflux, 2 h, 2.) -78 deg C, 30 min

2: 91 percent / 4-(N,N-dimethylamino)pyridine, triethylamine / CH₂Cl₂; dimethylformamide / 10 h / Ambient temperature

With dmap; oxalyl dichloride; tetrabutylammonium borohydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;