methyl (2-(((benzyloxy)carbonyl)amino)ethanethioyl)-L-leucinate

Base Information

• Chemical Name: methyl (2-(((benzyloxy)carbonyl)amino)ethanethioyl)-L-leucinate
• CAS No.: 128421-83-0
• Molecular Formula: C₁₇H₂₄N₂O₄S
• Molecular Weight: 352.455
• Mol file: 128421-83-0.mol

Synonyms:methyl (2-(((benzyloxy)carbonyl)amino)ethanethioyl)-L-leucinate

Chemical Property of methyl (2-(((benzyloxy)carbonyl)amino)ethanethioyl)-L-leucinate

Chemical Property:

Purity/Quality:

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Technology Process of methyl (2-(((benzyloxy)carbonyl)amino)ethanethioyl)-L-leucinate

There total 2 articles about methyl (2-(((benzyloxy)carbonyl)amino)ethanethioyl)-L-leucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

N-benzyloxycarbonylglycyl-L-leucine methyl ester (17331-93-0) → methyl (2-(((benzyloxy)carbonyl)amino)ethanethioyl)-L-leucinate (128421-83-0)

Guidance literature:

With Lawessons reagent; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 90 - 110 ℃; for 1.5h;

Reference yield: 62.0%

N-benzyloxycarbonylglycinal (67561-03-9) + methyl (L)-leucinate hydrochloride (7517-19-3) → methyl (2-(((benzyloxy)carbonyl)amino)ethanethioyl)-L-leucinate (128421-83-0)

Guidance literature:

With sulfur; sodiumsulfide nonahydrate; copper dichloride; In tetrahydrofuran; at 50 ℃; for 10h; Schlenk technique;

DOI:10.1021/acs.orglett.1c03370

Reference yield: 50.0%

methyl (2-(((benzyloxy)carbonyl)amino)ethanethioyl)-L-leucinate (128421-83-0) → Z-Gly-ψ(CSNH)-Leu-NH2

Guidance literature:

With ammonia; In methanol; at 5 ℃; for 72h;

upstream raw materials:

N-benzyloxycarbonylglycyl-L-leucine methyl ester

N-benzyloxycarbonylglycinal

methyl (L)-leucinate hydrochloride

Downstream raw materials:

Z-Gly-ψ(CH2NH)-Leu-OMe

Z-Gly-ψ(CSNH)-Leu