(E)-3-(4-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]-thiophen-3-yl)oxy)phenyl)-N-methylacrylamide

Base Information

• Chemical Name: (E)-3-(4-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]-thiophen-3-yl)oxy)phenyl)-N-methylacrylamide
• CAS No.: 1622307-83-8
• Molecular Formula: C₂₄H₁₉NO₄S
• Molecular Weight: 417.485

Synonyms:(E)-3-(4-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]-thiophen-3-yl)oxy)phenyl)-N-methylacrylamide

Chemical Property of (E)-3-(4-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]-thiophen-3-yl)oxy)phenyl)-N-methylacrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(4-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]-thiophen-3-yl)oxy)phenyl)-N-methylacrylamide

There total 8 articles about (E)-3-(4-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]-thiophen-3-yl)oxy)phenyl)-N-methylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(E)-3-(4-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid (1622307-14-5) + methylamine hydrochloride (593-51-1) → (E)-3-(4-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]-thiophen-3-yl)oxy)phenyl)-N-methylacrylamide (1622307-83-8)

Guidance literature:

(E)-3-(4-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; for 0.166667h;

methylamine hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1021/acs.jmedchem.7b01682

Reference yield:

3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene (176672-06-3) → (E)-3-(4-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]-thiophen-3-yl)oxy)phenyl)-N-methylacrylamide (1622307-83-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: trifluoroacetic acid; dihydrogen peroxide / dichloromethane / 1.67 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C

2.2: 18 h / 80 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

4.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

5.1: boron tribromide / dichloromethane; n-heptane / 1.67 h / 0 °C

6.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h

6.2: 6 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; lithium aluminium tetrahydride; dihydrogen peroxide; boron tribromide; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; n-heptane; dichloromethane; N,N-dimethyl-formamide; mineral oil; 4.1: |Heck Reaction;

DOI:10.1021/acs.jmedchem.7b01682

Reference yield:

2-(4'-methoxyphenyl)-6-methoxybenzothiophene (63675-74-1) → (E)-3-(4-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]-thiophen-3-yl)oxy)phenyl)-N-methylacrylamide (1622307-83-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 3 h / 0 - 25 °C

2.1: trifluoroacetic acid; dihydrogen peroxide / dichloromethane / 1.67 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C

3.2: 18 h / 80 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

5.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

6.1: boron tribromide / dichloromethane; n-heptane / 1.67 h / 0 °C

7.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h

7.2: 6 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; lithium aluminium tetrahydride; dihydrogen peroxide; boron tribromide; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; n-heptane; dichloromethane; N,N-dimethyl-formamide; mineral oil; 5.1: |Heck Reaction;

DOI:10.1021/acs.jmedchem.7b01682

upstream raw materials:

(E)-3-(4-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

methylamine hydrochloride

3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1622307-83-8 (E)-3-(4-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]-thiophen-3-yl)oxy)phenyl)-N-methylacrylamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send