6-{4-[(E)-3-(pyridin-3-yl)acryloylamino]-3-fluorophenyl}-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]nicotinamide

Base Information

Chemical Name:6-{4-[(E)-3-(pyridin-3-yl)acryloylamino]-3-fluorophenyl}-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]nicotinamide
CAS No.:1246495-00-0
Molecular Formula:C₂₉H₃₃FN₆O₂
Molecular Weight:516.618
Hs Code.:

Synonyms:6-{4-[(E)-3-(pyridin-3-yl)acryloylamino]-3-fluorophenyl}-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]nicotinamide

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Chemical Property of 6-{4-[(E)-3-(pyridin-3-yl)acryloylamino]-3-fluorophenyl}-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]nicotinamide

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Technology Process of 6-{4-[(E)-3-(pyridin-3-yl)acryloylamino]-3-fluorophenyl}-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]nicotinamide

There total 4 articles about 6-{4-[(E)-3-(pyridin-3-yl)acryloylamino]-3-fluorophenyl}-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.4%

: 1246494-87-0
6-(4-amino-3-fluorophenyl)-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]nicotinamide

: 1126-72-3
(E)-3-(3-pyridyl)acrylic acid chloride

: 1246495-00-0
6-{4-[(E)-3-(pyridin-3-yl)acryloylamino]-3-fluorophenyl}-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]nicotinamide

Guidance literature:: 6-(4-amino-3-fluorophenyl)-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]nicotinamide; (E)-3-(3-pyridyl)acrylic acid chloride; With triethylamine; In dichloromethane; at 20 ℃; for 18h; Cooling;

With sodium hydroxide; In dichloromethane;

Reference yield:

: 1161013-89-3
6-Chloro-2-ethylamino-N-(2-(piperidin-1-yl)ethyl)nicotinamide

: 1246495-00-0
6-{4-[(E)-3-(pyridin-3-yl)acryloylamino]-3-fluorophenyl}-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol / 16 h / 100 °C / Inert atmosphere; Reflux

2: triethylamine / dichloromethane / 18 h / 20 °C / Cooling

With sodium hydrogencarbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; dichloromethane;

Reference yield:

: 38496-18-3
2,6-dichloropyridine-3-carboxylic acid

: 1246495-00-0
6-{4-[(E)-3-(pyridin-3-yl)acryloylamino]-3-fluorophenyl}-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: water / 120 h / 20 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 15 h / 20 °C

3: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol / 16 h / 100 °C / Inert atmosphere; Reflux

4: triethylamine / dichloromethane / 18 h / 20 °C / Cooling

With sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water;