1-(2-Bromobenzyl)piperidine

Base Information

• Chemical Name: 1-(2-Bromobenzyl)piperidine
• CAS No.: 1459-22-9
• Molecular Formula: C₁₂H₁₆BrN
• Molecular Weight: 254.17
• Hs Code.: 2933399090
• Mol file: 1459-22-9.mol

Synonyms:Piperidine,1-(o-bromobenzyl)- (7CI,8CI);

Chemical Property of 1-(2-Bromobenzyl)piperidine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.575
• Boiling Point: 299.076 °C at 760 mmHg
• Flash Point: 134.677 °C
• PSA: 3.24000
• Density: 1.323 g/cm³
• LogP: 3.37290

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Bromobenzyl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-Bromobenzyl)piperidine

There total 3 articles about 1-(2-Bromobenzyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-bromophenyl)(piperidin-1-yl)methanone (61153-35-3) → 1-(2-bromo-benzyl)-piperidine (1459-22-9)

Guidance literature:

With phenylsilane; [(k²-P,N)Mn(N(SiMe₃)₂)]; In benzene-d6; at 75 ℃; for 3h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1002/anie.201709441

Reference yield:

piperidine (110-89-4) + 2-bromobenzoic acid chloride (7154-66-7) → 1-(2-bromo-benzyl)-piperidine (1459-22-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: [(k²-P,N)Mn(N(SiMe₃)₂)]; phenylsilane / benzene-d6 / 3 h / 75 °C / Inert atmosphere; Glovebox; Sealed tube

With phenylsilane; [(k²-P,N)Mn(N(SiMe₃)₂)]; triethylamine; In dichloromethane; benzene-d6;

DOI:10.1002/anie.201709441

Reference yield:

→ 1-(2-bromo-benzyl)-piperidine (1459-22-9)

Guidance literature:

o-Brombenzylbromid, Piperidin;

upstream raw materials:

(2-bromophenyl)(piperidin-1-yl)methanone

piperidine

2-bromobenzoic acid chloride

Downstream raw materials:

C₁₂H₁₇NO₃Se

C₁₂H₁₇NOSe

C₁₂H₁₇NO₂Se

C₁₂H₁₇NSe

Refernces