61153-35-3

Basic information

• Product Name: CHEMBRDG-BB 5259339
• Synonyms: CHEMBRDG-BB 5259339;(2-Bromophenyl)(piperidin-1-yl)methanone;(2-Bromophenylcarbonyl)piperidine
• CAS NO: 61153-35-3
• Molecular Formula: C₁₂H₁₄BrNO
• Molecular Weight: 268.15
• Mol File: 61153-35-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: CHEMBRDG-BB 5259339(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMBRDG-BB 5259339(61153-35-3)
• EPA Substance Registry System: CHEMBRDG-BB 5259339(61153-35-3)

Safety Data

• Hazardous Substances Data: 61153-35-3(Hazardous Substances Data)

Usage

General Description

CHEMBRDG-BB 5259339 is a chemical compound with a molecular formula of C18H23FN4O2S and a molecular weight of 378.47 g/mol. It is an inhibitor of the enzyme BRAF(V600E) with potential antineoplastic activity. CHEMBRDG-BB 5259339 specifically targets and binds to the mutated BRAF(V600E) protein, inhibiting its activity and blocking the MAPK/ERK signaling pathway, which is frequently dysregulated in various types of cancer. By doing so, CHEMBRDG-BB 5259339 has the potential to inhibit the growth and proliferation of cancer cells harboring the BRAF(V600E) mutation, making it a promising candidate for cancer therapy.

Upstream product

• 110-89-4 piperidine 
• 7154-66-7 2-bromobenzoic acid chloride 
• 88-65-3 2-bromobenzoic-acid 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 1616609-91-6 (2-(benzo[d][1,3]dioxol-5-yl)phenyl)(piperidin-1-yl)methanone 
• 1459-22-9 1-(2-bromo-benzyl)-piperidine 
• 1425605-73-7 (2-(phenylethynyl)phenyl)(piperidin-1-yl)methanone 
• 23023-35-0 3-phenylisoquinolin-1-ylamine 
• 1261298-38-7 7-phenyl-2-[2-(1-piperidinylcarbonyl)phenyl]-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one 

Relevant articles and documents

Electrochemical Amide Bond Formation from Benzaldehydes and Amines: Oxidation by Cathodic-Generated Hydrogen Peroxide

Although amide bond formation from aldehydes and amines is a popular synthetic tool, most of the previously reported reactions depend on transition-metal catalysts or expensive oxidants. We considered that a more environmentally benign and safer approach could be achieved by electrochemistry. Nineteen benzamide derivatives were obtained with this reaction. NMR studies, cyclic voltammetry (CV) investigations, and control experiments showed that the corresponding intermediate, a hemiaminal, was transformed into the amide by oxidation with hydrogen peroxide generated in situ by cathodic reduction of molecular oxygen.

A Manganese Pre-Catalyst: Mild Reduction of Amides, Ketones, Aldehydes, and Esters

A new (N-phosphinoamidinate)manganese complex is shown to be a useful pre-catalyst for the hydrosilative reduction of carbonyl compounds, and in most cases at room temperature. The Mn-catalyzed reduction of tertiary amides to tertiary amines, with a useful scope, is demonstrated for the first time by use of this catalyst, and is competitive with the most effective transition-metal catalysts known for such transformations. Ketones, aldehydes, and esters were also successfully reduced under mild conditions by using this new Mn catalyst.

Synthesis of 1-aminoisoquinolines by gold(III)-mediated domino reactions from 2-alkynylbenzamides and ammonium acetate

A facile synthetic route toward pharmaceutically interesting 1-aminoisoquinoline derivatives by gold(III)-mediated domino reactions is described. This synthetic protocol starts from readily available 2-alkynylbenzamides and ammonium acetate and takes plac