1-Benzyl-2-(3-bromo-pyridine-4-carbonyl)-1H-indole-3-carboxylic acid diethylamide

Base Information

• Chemical Name: 1-Benzyl-2-(3-bromo-pyridine-4-carbonyl)-1H-indole-3-carboxylic acid diethylamide
• CAS No.: 214066-28-1
• Molecular Formula: C₂₆H₂₄BrN₃O₂
• Molecular Weight: 490.399
• Mol file: 214066-28-1.mol

Synonyms:1-Benzyl-2-(3-bromo-pyridine-4-carbonyl)-1H-indole-3-carboxylic acid diethylamide

Chemical Property of 1-Benzyl-2-(3-bromo-pyridine-4-carbonyl)-1H-indole-3-carboxylic acid diethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Benzyl-2-(3-bromo-pyridine-4-carbonyl)-1H-indole-3-carboxylic acid diethylamide

There total 4 articles about 1-Benzyl-2-(3-bromo-pyridine-4-carbonyl)-1H-indole-3-carboxylic acid diethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethylamine (109-89-7) + 1-Benzyl-2-(3-bromo-pyridine-4-carbonyl)-1H-indole-3-carbonyl chloride → 1-Benzyl-2-(3-bromo-pyridine-4-carbonyl)-1H-indole-3-carboxylic acid diethylamide (214066-28-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h; Yield given;

DOI:10.3987/COM-98-8192

Reference yield:

3-Bromopyridine (626-55-1,163928-56-1) → 1-Benzyl-2-(3-bromo-pyridine-4-carbonyl)-1H-indole-3-carboxylic acid diethylamide (214066-28-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) iPr₂NH, nBuLi in hexane / 1) THF, -96 deg C, 2) THF, 1 h, 96 deg C

2: (COCl)2 / CH₂Cl₂ / 2 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

With n-butyllithium; oxalyl dichloride; triethylamine; diisopropylamine; In dichloromethane;

DOI:10.3987/COM-98-8192

Reference yield:

1-benzyl-2-(3-bromoisonicotinoyl)indole-3-carboxylic acid (184473-69-6) → 1-Benzyl-2-(3-bromo-pyridine-4-carbonyl)-1H-indole-3-carboxylic acid diethylamide (214066-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: (COCl)2 / CH₂Cl₂ / 2 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

With oxalyl dichloride; triethylamine; In dichloromethane;

DOI:10.3987/COM-98-8192

upstream raw materials:

diethylamine

3-Bromopyridine

1-benzylindole-2,3-dicarboxylic anhydride

1-benzyl-2-(3-bromoisonicotinoyl)indole-3-carboxylic acid

Downstream raw materials:

1-Benzyl-2-[(3-bromo-pyridin-4-yl)-hydroxy-methyl]-1H-indole-3-carboxylic acid diethylamide