(5R)-3,3,6c-trimethyl-6t-(4-nitro-benzylideneamino)-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester

Base Information

Chemical Name:(5R)-3,3,6c-trimethyl-6t-(4-nitro-benzylideneamino)-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester
CAS No.:36273-77-5
Molecular Formula:C₂₃H₂₃N₃O₅S
Molecular Weight:453.519
Hs Code.:

(5<i>R</i>)-3,3,6<i>c</i>-trimethyl-6<i>t</i>-(4-nitro-benzylideneamino)-7-oxo-(5<i>r</i><i>H</i>)-4-thia-1-aza-bicyclo[3.2.0]heptane-2<i>c</i>-carboxylic acid benzyl ester

Synonyms:(5R)-3,3,6c-trimethyl-6t-(4-nitro-benzylideneamino)-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester

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Chemical Property of (5R)-3,3,6c-trimethyl-6t-(4-nitro-benzylideneamino)-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester

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Technology Process of (5R)-3,3,6c-trimethyl-6t-(4-nitro-benzylideneamino)-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester

There total 11 articles about (5R)-3,3,6c-trimethyl-6t-(4-nitro-benzylideneamino)-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 36273-76-4
6β-(4-nitro-benzylideneamino)-penicillanic acid benzyl ester

: 74-88-4
methyl iodide

: 36273-77-5
(5R)-3,3,6c-trimethyl-6t-(4-nitro-benzylideneamino)-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester

Guidance literature:: 6β-(4-nitro-benzylideneamino)-penicillanic acid benzyl ester; With phenyllithium; In tetrahydrofuran; at -78 ℃;

methyl iodide; In tetrahydrofuran; at -78 - 20 ℃; for 0.5h;
DOI:10.1016/S0960-894X(01)00470-X

Reference yield:

: 49626-62-2
6α-azido-penicillanic acid benzyl ester

: 36273-77-5
(5R)-3,3,6c-trimethyl-6t-(4-nitro-benzylideneamino)-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / PtO₂ / benzene

2: benzene

3: (i) PhLi, THF, (ii) /BRN= 969135/, DMF

With hydrogen; platinum(IV) oxide; In benzene;
DOI:10.1021/jo00918a003

Reference yield:

: 49626-59-7
D-penicillamine benzyl ester

: 36273-77-5
(5R)-3,3,6c-trimethyl-6t-(4-nitro-benzylideneamino)-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂

2: Et₃N / CH₂Cl₂

3: H₂ / PtO₂ / benzene

4: benzene

5: (i) PhLi, THF, (ii) /BRN= 969135/, DMF

With hydrogen; triethylamine; platinum(IV) oxide; In dichloromethane; benzene;
DOI:10.1021/jo00918a003