36273-76-4

Upstream product

• 64519-71-7 6-aminopenicillanic acid benzyl ester 
• 555-16-8 4-nitrobenzaldehdye 
• 36273-76-4 6ξ-(4-nitro-benzylideneamino)-penicillanic acid benzyl ester 
• 551-16-6 6-Aminopenicillanic Acid 
• 3956-31-8 benzyl (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 
• 100-39-0 benzyl bromide 

Downstream Products

• 40353-06-8 (5R)-6c-hydroxymethyl-3,3-dimethyl-6t-(4-nitro-benzylideneamino)-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester 
• 41102-60-7 (5R)-6c-((Ξ)-1-hydroxy-ethyl)-3,3-dimethyl-7-oxo-6t-(2-phenoxy-acetylamino)-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester 
• 41102-56-1 (5R)-6c-((Ξ)-1-hydroxy-ethyl)-3,3-dimethyl-6t-(4-nitro-benzylideneamino)-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester 
• 41102-58-3 (5R)-3,3-dimethyl-6-(4-nitro-benzylideneamino)-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c,6c-dicarboxylic acid dibenzyl ester 
• 41102-69-6 (2R)-4ξ-cyano-3',3'-dimethyl-5ξ-(4-nitro-phenyl)-7'-oxo-(2rC^5',5't'H,6'r'N)-spiro[pyrrolidine-2,6'-(4-thia-1-aza-bicyclo[3.2.0]heptane)]-2't'-carboxylic acid benzyl ester 
• 41102-55-0 (5R)-6c-(2-cyano-ethyl)-3,3-dimethyl-6t-(4-nitro-benzylideneamino)-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester 
• 41102-57-2 (5R)-3,3-dimethyl-6-(4-nitro-benzylideneamino)-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c,6c-dicarboxylic acid 2-benzyl ester 6-methyl ester 
• 36273-77-5 (5R)-3,3,6c-trimethyl-6t-(4-nitro-benzylideneamino)-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester 
• 36273-78-6 (5R)-6t-amino-3,3,6c-trimethyl-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester 
• 388568-32-9 (2S,5R,6R)-3,3,6-Trimethyl-6-[(R)-5-(4-nitro-benzyloxycarbonyl)-5-(4-nitro-benzyloxycarbonylamino)-pentanoylamino]-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester 
• 49626-56-4 6α-(4-nitro-benzylideneamino)-penicillanic acid benzyl ester 
• 61-33-6 penicillin G 
• 1254-56-4 benzyl (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 
• 3956-31-8 benzyl (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 

Relevant academic research and scientific papers

Contrasting fates for 6-α-methylpenicillin N upon oxidation by deacetoxycephalosporin C synthase (DAOCS) and deacetoxy/deacetylcephalosporin C synthase (DAOC/DACS)

6-α-Methylpenicillin N was synthesised via known routes from 6-aminopenicillanic acid, and tested as a substrate for recombinant DAOCS and DAOC/DACS. Incubation with DAOCS resulted in conversion of 2-oxoglutarate without oxidation of the penicillin substrate ('uncoupled turnover'). Incubation with DAOC/DACS resulted in oxidation to the cephem aldehyde. This is the first example of substrate-induced 'uncoupled turnover', which has been proposed to be an editing mechanism for these enzymes. Elsevier Science Ltd. All rights reserved.

Penicillin derivatives and compositions containing them

A compound of formula (I) or a pharmaceutically acceptable salt or in vivo hydrolyzable ester thereof: STR1 wherein R is phenyl 4-hydroxy phenyl, or a 5- 6- membered heterocyclic ring containing up to three heteroatoms selected from oxygen, sulphur or nit