Technology Process of (2R,3S,4R,5R)-3-[(tert-butyldimethylsilyl)oxy]-5-methoxy-7-[(4-methoxybenzyl)oxy]-2,4-dimethylheptan-1-ol
There total 8 articles about (2R,3S,4R,5R)-3-[(tert-butyldimethylsilyl)oxy]-5-methoxy-7-[(4-methoxybenzyl)oxy]-2,4-dimethylheptan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
methanol; lithium borohydride;
In
tetrahydrofuran;
at 0 ℃;
for 0.75h;
Inert atmosphere;
DOI:10.1055/s-0032-1317700
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1H-imidazole / dichloromethane / 0.25 h / 0 °C / Inert atmosphere
1.2: 1 h / 0 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere
2.2: 2 h / 20 °C / Inert atmosphere
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C / Inert atmosphere
4.1: oxalyl dichloride; triethylamine / dichloromethane; dimethyl sulfoxide / 2.5 h / -78 - 20 °C / Inert atmosphere
5.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
5.2: 1 h / 0 °C / Inert atmosphere
5.3: 1.5 h / -78 - 0 °C / Inert atmosphere
6.1: 2,6-dimethylpyridine / dichloromethane / 0.33 h / 0 °C / Inert atmosphere
6.2: Inert atmosphere
7.1: lithium borohydride; methanol / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere
With
1H-imidazole; 2,6-dimethylpyridine; methanol; lithium borohydride; oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; sodium hydride; triethylamine;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
5.3: |Evans Aldol Reaction;
DOI:10.1055/s-0032-1317700
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
1.2: 1 h / 0 °C / Inert atmosphere
1.3: 1.5 h / -78 - 0 °C / Inert atmosphere
2.1: 2,6-dimethylpyridine / dichloromethane / 0.33 h / 0 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: lithium borohydride; methanol / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere
With
2,6-dimethylpyridine; methanol; lithium borohydride; di-n-butylboryl trifluoromethanesulfonate;
In
tetrahydrofuran; dichloromethane;
1.3: |Evans Aldol Reaction;
DOI:10.1055/s-0032-1317700
![(S)-4-benzyl-3-[(2S,3R,4R,5R)-3-[(tert-butyldimethylsilyl)oxy]-5-methoxy-7-[(4-methoxybenzyl)oxy]-2,4-dimethylheptanoyl]oxazolidin-2-one](/Databaselist/images/loading.webp)
