603994-09-8Relevant articles and documents
Approaches towards the total synthesis of carolacton: Synthesis of C1-C16 fragment
Reddy, Sheri Venkata,Prasanna Kumar,Ramakrishna, Kallaganti V.S.,Sharma, Gangavaram V.M.
, p. 2018 - 2022 (2015)
Abstract A stereoselective synthesis of the C1-C16 segment of biofilm inhibitor carolacton has been achieved. The synthetic strategy involves Sharpless asymmetric epoxidation, Roush crotylation, Steglich esterification, RCM reaction and selective reduction of a disubstituted olefin in the presence of a trisubstituted olefin using in situ generated diimide.
Studies toward the total synthesis of carolacton
Sabitha, Gowravaram,Shankaraiah,Prasad, M.Nagendra,S. Yadav, Jhillu
, p. 251 - 259 (2013/02/23)
An efficient synthesis of the C1-C19 segment of carolacton is described, starting from d-ribose, (-)-β-citronellene and a homopropargylic alcohol, and which employs a Nozaki-Hiyama-Kishi (NHK) coupling as the key step. Other important steps are cross-metathesis and Evans aldol reactions. Georg Thieme Verlag Stuttgart New York.
Stereochemical assignment of the C23-C35 portion of sphinxolide/reidispongiolide class of natural products by asymmetric synthesis
Zampella, Angela,Sepe, Valentina,D'Orsi, Rosa,Bifulco, Giuseppe,Bassarello, Carla,D'Auria, Maria Valeria
, p. 1787 - 1798 (2007/10/03)
The absolute configuration of the seven stereogenic centers contained in the C23-C35 portion of reidispongiolide A is determined by asymmetric synthesis of the corresponding fragment obtained by ozonolysis of the natural macrolide.