[4-(4-nitro-phenoxycarbonylmethylsulfanylmethyl)-1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-3-ylmethylsulfanyl]-acetic acid 4-nitro-phenyl ester

Base Information

• Chemical Name: [4-(4-nitro-phenoxycarbonylmethylsulfanylmethyl)-1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-3-ylmethylsulfanyl]-acetic acid 4-nitro-phenyl ester
• CAS No.: 381725-24-2
• Molecular Formula: C₂₂H₂₀N₂O₁₀S₃
• Molecular Weight: 568.606

Synonyms:[4-(4-nitro-phenoxycarbonylmethylsulfanylmethyl)-1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-3-ylmethylsulfanyl]-acetic acid 4-nitro-phenyl ester

Chemical Property of [4-(4-nitro-phenoxycarbonylmethylsulfanylmethyl)-1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-3-ylmethylsulfanyl]-acetic acid 4-nitro-phenyl ester

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(4-nitro-phenoxycarbonylmethylsulfanylmethyl)-1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-3-ylmethylsulfanyl]-acetic acid 4-nitro-phenyl ester

There total 5 articles about [4-(4-nitro-phenoxycarbonylmethylsulfanylmethyl)-1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-3-ylmethylsulfanyl]-acetic acid 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + (4-chlorocarbonylmethylsulfanylmethyl-1,1-dioxo-2,5-dihydro-1H-1λ6-thiophen-3-ylmethylsulfanyl)-acetyl chloride → [4-(4-nitro-phenoxycarbonylmethylsulfanylmethyl)-1,1-dioxo-2,5-dihydro-1H-1λ6-thiophen-3-ylmethylsulfanyl]-acetic acid 4-nitro-phenyl ester (381725-24-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 8h;

DOI:10.1021/ol016586r

Reference yield:

3,4-dimethyl-3-sulfolene (18214-56-7) → [4-(4-nitro-phenoxycarbonylmethylsulfanylmethyl)-1,1-dioxo-2,5-dihydro-1H-1λ6-thiophen-3-ylmethylsulfanyl]-acetic acid 4-nitro-phenyl ester (381725-24-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 42 percent / NBS; BPO / CHCl₃ / 15 h / Heating

2: 71 percent / Et₃N / tetrahydrofuran; methanol

3: 90 percent / aq.HCl / -20 - 70 °C

4: SOCl₂ / dimethylformamide / 12 h / 20 °C

5: 9.88 g / Et₃N / CH₂Cl₂ / 8 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; thionyl chloride; triethylamine; dibenzoyl peroxide; In tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/ol016586r

Reference yield:

3,4-bis-(bromomethyl)-2,5-dihydrothiophene 1,1-dioxide (18214-57-8) → [4-(4-nitro-phenoxycarbonylmethylsulfanylmethyl)-1,1-dioxo-2,5-dihydro-1H-1λ6-thiophen-3-ylmethylsulfanyl]-acetic acid 4-nitro-phenyl ester (381725-24-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 71 percent / Et₃N / tetrahydrofuran; methanol

2: 90 percent / aq.HCl / -20 - 70 °C

3: SOCl₂ / dimethylformamide / 12 h / 20 °C

4: 9.88 g / Et₃N / CH₂Cl₂ / 8 h / 20 °C

With hydrogenchloride; thionyl chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol016586r

upstream raw materials:

4-nitro-phenol

3,4-dimethyl-3-sulfolene

3,4-bis-(bromomethyl)-2,5-dihydrothiophene 1,1-dioxide

bis(methoxycarbonylmethyl-thiomethyl)-2,5-dihydrothiophene-1,1-dioxide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 381725-24-2 [4-(4-nitro-phenoxycarbonylmethylsulfanylmethyl)-1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-3-ylmethylsulfanyl]-acetic acid 4-nitro-phenyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send