Technology Process of tert-butyl {2,6-dimethyl-4-[7-propyl-5-(3,3,3-trifluoropropoxy)oxazolo[5,4-d]pyrimidin-2-yl]phenoxy}acetate
There total 9 articles about tert-butyl {2,6-dimethyl-4-[7-propyl-5-(3,3,3-trifluoropropoxy)oxazolo[5,4-d]pyrimidin-2-yl]phenoxy}acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3,3,3-Trifluoropropanol;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
for 0.0833333h;
tert-butyl [4-(5-methanesulfonyl-7-propyloxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]acetate;
In
N,N-dimethyl-formamide; mineral oil;
at 20 - 80 ℃;
for 2.25h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: trichlorophosphate / 36 h / 70 °C
2.1: boron tribromide / dichloromethane / 4 h / -20 - 20 °C
2.2: -20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C
4.1: iron(III)-acetylacetonate / tetrahydrofuran / 3 h / -78 - 20 °C / Inert atmosphere
5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C
6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h
6.2: 2.25 h / 20 - 80 °C
With
iron(III)-acetylacetonate; boron tribromide; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium methylate / ethanol; methanol / 0.25 h
1.2: 3 h / 60 °C
2.1: sodium hydroxide / water; 1-methyl-pyrrolidin-2-one / 0.5 h / 0 °C
2.2: 2 h / 0 °C
2.3: pH 2
3.1: trichlorophosphate / 36 h / 70 °C
4.1: boron tribromide / dichloromethane / 4 h / -20 - 20 °C
4.2: -20 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C
6.1: iron(III)-acetylacetonate / tetrahydrofuran / 3 h / -78 - 20 °C / Inert atmosphere
7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C
8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h
8.2: 2.25 h / 20 - 80 °C
With
iron(III)-acetylacetonate; sodium methylate; boron tribromide; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; trichlorophosphate;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
