N-(4,6-dihydroxy-2-methylsulfanyl-pyrimidin-5-yl)-4-methoxy-3,5-dimethyl-benzamide

Base Information

Chemical Name:N-(4,6-dihydroxy-2-methylsulfanyl-pyrimidin-5-yl)-4-methoxy-3,5-dimethyl-benzamide
CAS No.:1315456-72-4
Molecular Formula:C₁₅H₁₇N₃O₄S
Molecular Weight:335.384
Hs Code.:

Synonyms:N-(4,6-dihydroxy-2-methylsulfanyl-pyrimidin-5-yl)-4-methoxy-3,5-dimethyl-benzamide

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Chemical Property of N-(4,6-dihydroxy-2-methylsulfanyl-pyrimidin-5-yl)-4-methoxy-3,5-dimethyl-benzamide

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Technology Process of N-(4,6-dihydroxy-2-methylsulfanyl-pyrimidin-5-yl)-4-methoxy-3,5-dimethyl-benzamide

There total 3 articles about N-(4,6-dihydroxy-2-methylsulfanyl-pyrimidin-5-yl)-4-methoxy-3,5-dimethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1315456-71-3
sodium 4,6-dihydroxy-5-(4-methoxy-3,5-dimethyl-benzoylamino)-pyrimidine-2-thiolate

: 74-88-4
methyl iodide

: 1315456-72-4
N-(4,6-dihydroxy-2-methylsulfanyl-pyrimidin-5-yl)-4-methoxy-3,5-dimethyl-benzamide

Guidance literature:: sodium 4,6-dihydroxy-5-(4-methoxy-3,5-dimethyl-benzoylamino)-pyrimidine-2-thiolate; With sodium hydroxide; In 1-methyl-pyrrolidin-2-one; water; at 0 ℃; for 0.5h;

methyl iodide; In 1-methyl-pyrrolidin-2-one; water; at 0 ℃; for 2h;

With hydrogenchloride; In 1-methyl-pyrrolidin-2-one; water; pH=2;

Reference yield:

: 21668-34-8
3,5-dimethyl-4-methoxybenzoic acid chloride

: 1315456-72-4
N-(4,6-dihydroxy-2-methylsulfanyl-pyrimidin-5-yl)-4-methoxy-3,5-dimethyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 2 h / 0 °C

2.1: sodium methylate / ethanol; methanol / 0.25 h

2.2: 3 h / 60 °C

3.1: sodium hydroxide / water; 1-methyl-pyrrolidin-2-one / 0.5 h / 0 °C

3.2: 2 h / 0 °C

3.3: pH 2

With sodium methylate; triethylamine; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water;

Reference yield:

: 1315456-69-9
2-(4-methoxy-3,5-dimethyl-benzoylamino)-malonic acid diethyl ester

: 1315456-72-4
N-(4,6-dihydroxy-2-methylsulfanyl-pyrimidin-5-yl)-4-methoxy-3,5-dimethyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium methylate / ethanol; methanol / 0.25 h

1.2: 3 h / 60 °C

2.1: sodium hydroxide / water; 1-methyl-pyrrolidin-2-one / 0.5 h / 0 °C

2.2: 2 h / 0 °C

2.3: pH 2

With sodium methylate; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; water;