sodium 4,6-dihydroxy-5-(4-methoxy-3,5-dimethyl-benzoylamino)-pyrimidine-2-thiolate

Base Information

Chemical Name:sodium 4,6-dihydroxy-5-(4-methoxy-3,5-dimethyl-benzoylamino)-pyrimidine-2-thiolate
CAS No.:1315456-71-3
Molecular Formula:C₁₄H₁₄N₃O₄S*Na
Molecular Weight:343.339
Hs Code.:

Synonyms:sodium 4,6-dihydroxy-5-(4-methoxy-3,5-dimethyl-benzoylamino)-pyrimidine-2-thiolate

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Chemical Property of sodium 4,6-dihydroxy-5-(4-methoxy-3,5-dimethyl-benzoylamino)-pyrimidine-2-thiolate

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Technology Process of sodium 4,6-dihydroxy-5-(4-methoxy-3,5-dimethyl-benzoylamino)-pyrimidine-2-thiolate

There total 2 articles about sodium 4,6-dihydroxy-5-(4-methoxy-3,5-dimethyl-benzoylamino)-pyrimidine-2-thiolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1315456-69-9
2-(4-methoxy-3,5-dimethyl-benzoylamino)-malonic acid diethyl ester

: 17356-08-0
thiourea

: 1315456-71-3
sodium 4,6-dihydroxy-5-(4-methoxy-3,5-dimethyl-benzoylamino)-pyrimidine-2-thiolate

Guidance literature:: thiourea; With sodium methylate; In methanol; ethanol; for 0.25h;

2-(4-methoxy-3,5-dimethyl-benzoylamino)-malonic acid diethyl ester; In methanol; ethanol; at 60 ℃; for 3h;

Reference yield:

: 21668-34-8
3,5-dimethyl-4-methoxybenzoic acid chloride

: 1315456-71-3
sodium 4,6-dihydroxy-5-(4-methoxy-3,5-dimethyl-benzoylamino)-pyrimidine-2-thiolate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 2 h / 0 °C

2.1: sodium methylate / ethanol; methanol / 0.25 h

2.2: 3 h / 60 °C

With sodium methylate; triethylamine; In methanol; ethanol; dichloromethane;

Reference yield: 67.0%

: 1315456-71-3
sodium 4,6-dihydroxy-5-(4-methoxy-3,5-dimethyl-benzoylamino)-pyrimidine-2-thiolate

: 74-88-4
methyl iodide

: 1315456-72-4
N-(4,6-dihydroxy-2-methylsulfanyl-pyrimidin-5-yl)-4-methoxy-3,5-dimethyl-benzamide

Guidance literature:: sodium 4,6-dihydroxy-5-(4-methoxy-3,5-dimethyl-benzoylamino)-pyrimidine-2-thiolate; With sodium hydroxide; In 1-methyl-pyrrolidin-2-one; water; at 0 ℃; for 0.5h;

methyl iodide; In 1-methyl-pyrrolidin-2-one; water; at 0 ℃; for 2h;

With hydrogenchloride; In 1-methyl-pyrrolidin-2-one; water; pH=2;