4-methyl-1-(2-((2R)-1-[(2-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperidine

Base Information

Chemical Name:4-methyl-1-(2-((2R)-1-[(2-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperidine
CAS No.:1314696-26-8
Molecular Formula:C₁₈H₂₇N₃O₄S
Molecular Weight:381.496
Hs Code.:

Synonyms:4-methyl-1-(2-((2R)-1-[(2-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperidine

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Chemical Property of 4-methyl-1-(2-((2R)-1-[(2-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperidine

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Technology Process of 4-methyl-1-(2-((2R)-1-[(2-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperidine

There total 5 articles about 4-methyl-1-(2-((2R)-1-[(2-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 201039-15-8
(R)-2-[2-(4-methyl-piperidin-1-yl)ethyl]pyrrolidine

: 1314696-26-8
4-methyl-1-(2-((2R)-1-[(2-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperidine

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.05.010

Reference yield:

: 1314696-16-6
tert-butyl (2R)-2-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]pyrrolidine-1-carboxylate

: 1314696-26-8
4-methyl-1-(2-((2R)-1-[(2-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 50 °C

3: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2011.05.010

Reference yield:

: 61350-65-0
(R)-2-(pyrrolidin-2-yl)acetic acid

: 1314696-26-8
4-methyl-1-(2-((2R)-1-[(2-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 50 °C

5: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.05.010