57623-73-1

Upstream product

• 91-40-7 2-(phenylamino)benzoic acid 
• 62-53-3 aniline 
• 88-67-5 2-Iodobenzoic acid 

Downstream Products

• 50495-81-3 N-benzoyl-N-phenyl-anthranilic acid 
• 52069-22-4 N-phenyl-anthranilic acid-anhydride 
• 578-95-0 10H-acridin-9-one 
• 59238-62-9 N,N-Bis-(2-anilinobenzoyl)-11-bromundecylamin 
• 76681-81-7 1-phenyl-3-methyl-2,4-(1H,3H)quinazolinedione 
• 49604-61-7 N-methyl-2-(phenylamino)benzamide 
• 91-40-7 2-(phenylamino)benzoic acid 
• 76681-85-1 N-<2-((methylamino)carbonyl)phenyl>-2-oxo-N-phenylglycine methyl ester 
• 860732-17-8 N-phenyl-N-(N-phenyl-anthraniloyl)-anthranilic acid 
• 1211-19-4 2-phenylaminobenzamide 
• 1316852-06-8 14-(3-(trifluoromethyl)phenyl)-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one 
• 1316852-08-0 14-phenyl-1,2-dihydroquinolino[2',3':3,4]-pyrrolo[2,1-b]quinazoline-5,8(13H)-dione 
• 1316852-11-5 8-acetyloxy-14-phenyl-1,2-dihydroquinolino-[2',3':3,4]pyrrolo[2,1-b]quinazolin-5-one 
• 1316852-13-7 8-chloro-14-phenyl-1,2-dihydroquinolino-[2',3':3,4]pyrrolo[2,1-b]quinazolin-5-one 

Relevant academic research and scientific papers

Synthesis and investigation of anti-inflammatory activity of novel nitric oxide donating hybrid drugs

A small library of nitric oxide donating groups, 4-acetamidophenyl-2-[{2- (nitrooxy)ethyl}(phenyl) amino]benzoate (5a-e) possessing a variety of substituents (-H, -NO2, -CH3, -acetamidophenyl, -SO 2NH2) attached to the fourth position of phenyl ring were synthesized and evaluated for anti-inflammatory, analgesic and ulcerogenic potential. Structure-activity relationship data showed that the 2-phenylaminobenzoic acid skeleton is required for selective COX-2 inhibition. Among all compounds 4-acetamidophenyl-2-[{2-(nitrooxy)ethyl}(phenyl)amino] benzoate (5a) has shown potent anti-inflammatory activity while 4-acetamidophenyl-2-[{4-{(4-acetamidophenoxy)carbonyl} phenyl}{2-(nitrooxy) ethyl}amino]benzoate (5d) has shown potent analgesic activity compared to standard drug diclofenac.

Intramolecular N-aza-amidoalkylation in association with Witkop-Winterfeldt oxidation as the key step to synthesize Luotonin-A analogues

An expedient four-step approach for the synthesis of a short library of original analogues of the Topo-I Luotonin-A inhibitor, substituted at their C8- and N15-positions, was investigated. This consists of Rutaecarpines formation, their Witkop-Winterfeldt oxidation followed ultimately with functional adjustment of the pyrroloquinolone intermediates. In the first step of these investigations, Rutaecarpines including the Topo-I poison Evodiamine were obtained via the new tandem N-acylation/aza-amidoalkylation using a nitrogen atom as an internal nucleophile with or without association with a decarboxylation.

NEW DS DNA BINDING FLUORESCENT DYES

The present invention is directed to a fluorescent dye comprising a benzothiazolium moiety and a pyrimidinium moiety connected by a mono-methine bridge, characterized in that (i) the 2-position of the pyrimidine carries a substituent which starts with a C

SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES WITH A CHAIN EXTENSION

The invention relates to substituted cyclohexyl-1,4-diamine derivatives, to a method for their production, to medicaments containing said compounds and to the use of substituted cyclohexyl-1,4-diamine derivatives for producing medicaments.