N²-(1-Benzyl-piperidin-4-yl)-N²-ethyl-6-fluoro-N³-isopropylidene-pyridine-2,3-diamine

Base Information

• Chemical Name: N²-(1-Benzyl-piperidin-4-yl)-N²-ethyl-6-fluoro-N³-isopropylidene-pyridine-2,3-diamine
• CAS No.: 181579-50-0
• Molecular Formula: C₂₂H₂₉FN₄
• Molecular Weight: 368.497

Synonyms:N²-(1-Benzyl-piperidin-4-yl)-N²-ethyl-6-fluoro-N³-isopropylidene-pyridine-2,3-diamine

Chemical Property of N²-(1-Benzyl-piperidin-4-yl)-N²-ethyl-6-fluoro-N³-isopropylidene-pyridine-2,3-diamine

Chemical Property:

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Technology Process of N²-(1-Benzyl-piperidin-4-yl)-N²-ethyl-6-fluoro-N³-isopropylidene-pyridine-2,3-diamine

There total 5 articles about N²-(1-Benzyl-piperidin-4-yl)-N²-ethyl-6-fluoro-N³-isopropylidene-pyridine-2,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Methoxypropene (116-11-0) + 1-benzyl-4-[N-ethyl-N-(6-fluoro-3-(amino)-2-pyridinyl)amino]piperidine (179557-99-4) → N2-(1-Benzyl-piperidin-4-yl)-N2-ethyl-6-fluoro-N3-isopropylidene-pyridine-2,3-diamine (181579-50-0)

Guidance literature:

With pyridinium p-toluenesulfonate;

DOI:10.1021/jm960158n

Reference yield:

4-amino-1-benzylpiperidine (50541-93-0) → N2-(1-Benzyl-piperidin-4-yl)-N2-ethyl-6-fluoro-N3-isopropylidene-pyridine-2,3-diamine (181579-50-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 78 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

2: 84 percent / lithium aluminum hydride / tetrahydrofuran / 16 h / Heating

3: 54 percent / K₂CO₃ / acetonitrile / 6 h / 0 - 20 °C

4: H₂ / palladium hydroxide / methanol

5: 99 percent / pyridinium p-toluenesulfonic acid

With pyridine; lithium aluminium tetrahydride; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

DOI:10.1021/jm960158n

Reference yield:

4-acetylamino-1-benzylpiperidine (50534-23-1) → N2-(1-Benzyl-piperidin-4-yl)-N2-ethyl-6-fluoro-N3-isopropylidene-pyridine-2,3-diamine (181579-50-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / lithium aluminum hydride / tetrahydrofuran / 16 h / Heating

2: 54 percent / K₂CO₃ / acetonitrile / 6 h / 0 - 20 °C

3: H₂ / palladium hydroxide / methanol

4: 99 percent / pyridinium p-toluenesulfonic acid

With lithium aluminium tetrahydride; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; palladium dihydroxide; In tetrahydrofuran; methanol; acetonitrile;

DOI:10.1021/jm960158n

upstream raw materials:

2-Methoxypropene

1-benzyl-4-[N-ethyl-N-(6-fluoro-3-(amino)-2-pyridinyl)amino]piperidine

4-amino-1-benzylpiperidine

4-acetylamino-1-benzylpiperidine

Downstream raw materials:

1-benzyl-4-[N-ethyl-N-((3-(1,1-dimethylethylamino)-6-fluoro)-2-pyridyl)amino]piperidine

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