3-morpholinobenzoyl chloride

Base Information

• Chemical Name: 3-morpholinobenzoyl chloride
• CAS No.: 221876-07-9
• Molecular Formula: C₁₁H₁₂ClNO₂
• Molecular Weight: 225.675
• Mol file: 221876-07-9.mol

Synonyms:3-morpholinobenzoyl chloride

Chemical Property of 3-morpholinobenzoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-morpholinobenzoyl chloride

There total 5 articles about 3-morpholinobenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(4-morpholinyl)benzoic acid (215309-00-5) → 3-morpholinobenzoyl chloride (221876-07-9)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2004.08.006

Reference yield:

oxalyl dichloride (79-37-8) + 3-(4-morpholinyl)benzoic acid (215309-00-5) → 3-morpholinobenzoyl chloride (221876-07-9)

Guidance literature:

In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

m-Fluorobenzonitrile (403-54-3) → 3-morpholinobenzoyl chloride (221876-07-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dimethyl sulfoxide / 72 h / 100 °C

2.1: sulfuric acid; water / 20 h / Heating / reflux

2.2: 0.25 h / 0 °C / pH 2

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

With oxalyl dichloride; sulfuric acid; water; N,N-dimethyl-formamide; In dichloromethane; dimethyl sulfoxide;

upstream raw materials:

3-(4-morpholinyl)benzoic acid

oxalyl dichloride

m-Fluorobenzonitrile

3-(morpholin-4-yl)benzonitrile

Downstream raw materials:

N-(3-nitro-4-methylphenyl)-3-morpholinobenzamide

bis-m-morpholinobenzoyl trisulfide

methyl 5-(3-morpholinophenyl)oxazole-4-carboxylate

5-(3-morpholinophenyl)oxazole-4-carboxylic acid