2,2-Dichloro-2-fluoroacetonitrile

Base Information

• Chemical Name: 2,2-Dichloro-2-fluoroacetonitrile
• CAS No.: 353-82-2
• Molecular Formula: C₂Cl₂FN
• Molecular Weight: 127.933
• Mol file: 353-82-2.mol

Synonyms:fluorodichloromethyl cyanide

Chemical Property of 2,2-Dichloro-2-fluoroacetonitrile

Chemical Property:

• Vapor Pressure: 252mmHg at 25°C
• Melting Point: -110°C
• Refractive Index: 1.3682
• Boiling Point: 33°C (estimate)
• Density: 1.3909

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-Dichloro-2-fluoroacetonitrile

There total 2 articles about 2,2-Dichloro-2-fluoroacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

hydrogen fluoride (7664-39-3,12381-92-9,32057-09-3,74835-82-8) + trichloroacetonitrile (545-06-2) → trifluoroacetonitrile (353-85-5) + chlorodifluoroacetonitrile (421-05-6) + fluorodichloromethyl cyanide (353-82-2)

Guidance literature:

chromyl fluoride; at 450°C, contact time 8.6 s, molar ratio of CCl3CN:HF 9:1;

Reference yield:

trichloroacetonitrile (545-06-2) → chlorodifluoroacetonitrile (421-05-6) + fluorodichloromethyl cyanide (353-82-2)

Guidance literature:

With chromium fluoride; hydrogen fluoride; at 450 ℃;

Reference yield: 100.0%

fluorodichloromethyl cyanide (353-82-2) + tris(trimethylsilyl) phosphite (1795-31-9) → bis(trimethylsilyl) [2,2-dichloro-2-fluoro-N-(trimethylsilyl)ethanimidoyl]phosphonate

Guidance literature:

at -5 - 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2017.07.075

upstream raw materials:

trichloroacetonitrile

hydrogen fluoride

Downstream raw materials:

2,2-Dichloro-2-fluoro-N-(4-methoxy-benzyl)-acetamidine

biphenyl

2,2-dichloro-2-fluoro-1-phenylethanone

2,4-bis-(dichloro-fluoro-methyl)-6-phenyl-[1,3,5]triazine

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