Tris(trimethylsilyl) phosphite

Base Information

• Chemical Name: Tris(trimethylsilyl) phosphite
• CAS No.: 1795-31-9
• Molecular Formula: C9H27O3PSi3
• Molecular Weight: 298.542
• Hs Code.: 29319000
• European Community (EC) Number: 679-684-3
• DSSTox Substance ID: DTXSID70170820
• Nikkaji Number: J128.132A
• Wikidata: Q83040831
• Mol file: 1795-31-9.mol

Synonyms:Tris(trimethylsilyl) phosphite;1795-31-9;TRIS(TRIMETHYLSILYL)PHOSPHITE;Phosphorous Acid Tris(trimethylsilyl) Ester;Silanol, trimethyl-, phosphite (3:1);tritrimethylsilyl phosphite;Tris(trimethylsily)phosphite;C9H27O3PSi3;TMSPi;Trimethylsilanol phosphite;tris-trimethylsilylphosphite;SCHEMBL269960;DTXSID70170820;MFCD00015588;Tris(Trimethylsilyl) Phosphite, 96%;AKOS015856795;Phosphorous acid tris(trimethylsilyl)ester;FT-0653588;P1217;Phosphorous acid, tris(trimethylsilyl) ester;EN300-31292;D92090;Tris(trimethylsilyl) phosphite, >=95.0% (GC);A812456;Silanol,1,1,1-trimethyl-, 1,1',1''-phosphite;J-011461;Silanol, 1,1,1-trimethyl-, 1,1',1''-phosphite

Chemical Property of Tris(trimethylsilyl) phosphite

Chemical Property:

• Vapor Pressure: 0.074mmHg at 25°C
• Refractive Index: n20/D 1.409(lit.)
• Boiling Point: 236.1 °C at 760 mmHg
• Flash Point: 96.6 °C
• PSA: 41.28000
• Density: 0.893 g/mL at 25 °C(lit.)
• LogP: 4.76780
• Sensitive.: Air & Moisture Sensitive
• Water Solubility.: Sparingly soluble in water.
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 298.10056132
• Heavy Atom Count: 16
• Complexity: 180

Purity/Quality:

98%, ^*data from raw suppliers

Tris(trimethylsilyl) phosphite ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)OP(O[Si](C)(C)C)O[Si](C)(C)C
• Uses: Tris(trimethylsilyl) Phosphite is used in the studies of bisphosphonic acids as effective inhibitor of glutamine synthetase, a promising approach for the discovery of novel drugs against tuberculosis. It also acts as a reagent in the preparation of substituted calix[4]arenes bearing one or two α-hydroxymethylphosphonic acid fragments at upper rim of macrocycle as inhibitors of glutathione S-transferase in vitro.

Technology Process of Tris(trimethylsilyl) phosphite

There total 17 articles about Tris(trimethylsilyl) phosphite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

bis(trimethylsilyl) phosphonate (3663-52-3) + N,N-diethyl-1,1,1-trimethylsilanamine (996-50-9) → tris(trimethylsilyl) phosphite (1795-31-9)

Guidance literature:

for 7h; Heating;

DOI:10.1021/jo00323a024

Reference yield: 82.0%

chloro-trimethyl-silane (75-77-4) → bis(trimethylsilyl) phosphonate (3663-52-3) + tris(trimethylsilyl) phosphite (1795-31-9)

Guidance literature:

With phosphonic Acid; triethylamine; In tetrahydrofuran; diethyl ether; for 6h; Heating;

DOI:10.1021/jo00323a024

Reference yield: 81.0%

chloro-trimethyl-silane (75-77-4) + foscarnet (63585-09-1,66706-14-7,111964-97-7) → tris(trimethylsilyl) phosphite (1795-31-9)

Guidance literature:

With pyridine; triethylamine; In tetrahydrofuran; water; for 2h; Ambient temperature;

DOI:10.1246/bcsj.55.239

upstream raw materials:

chloro-trimethyl-silane

foscarnet

bis(trimethylsilyl) phosphonate

N,N-diethyl-1,1,1-trimethylsilanamine

Downstream raw materials:

Bis(trimethylsilyl)trifluoracetyl-phosphonat

C₁₄H₂₅O₅PSi₂

C₂₄H₃₉O₄PSi₃

C₁₈H₃₅O₄PSi₃

Refernces

• 1、 MLynarz, Piotr,Rydzewska, Agata,Sliwinska, Sylwia,Szymczyk, Monika. "The Aza α-aminophosphonate macrocycle". . p. 1496 - 1501. Retrieved 2009.
• 2、 -. "Preparation method of phosphate or phosphite and secondary battery. (by machine translation)". Paragraph 0078; 0079. . Retrieved 2019/12/25.
• 3、 Górny Vel Górniak, Micha?,Kafarski, Pawe?. "Preparation of the library of fluorescent aromatic aminophosphonate phenyl and benzyl esters". . p. 511 - 519. Retrieved 2016/04/05.