421-05-6

Basic information

• Product Name: CHLORODIFLUOROACETONITRILE
• Synonyms: chlorodifluoro-acetonitril;CHLORODIFLUOROACETONITRILE;Chlorodifluoroacetonitrile97%;2-chloro-2,2-difluoroacetonitrile;2-chloro-2,2-difluoro-acetonitrile;2-chloro-2,2-difluoro-ethanenitrile
• CAS NO: 421-05-6
• Molecular Formula: C₂ClF₂N
• Molecular Weight: 111.48
• EINECS: 207-000-1
• Mol File: 421-05-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: -18°C
• Flash Point: °C
• Appearance: /
• Density: 1.442g/cm³
• CAS DataBase Reference: CHLORODIFLUOROACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: CHLORODIFLUOROACETONITRILE(421-05-6)
• EPA Substance Registry System: CHLORODIFLUOROACETONITRILE(421-05-6)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25
• Safety Statements: 36/37/39-45
• Hazardous Substances Data: 421-05-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C2ClF2N/c3-2(4,5)1-6

Upstream product

• 354-28-9 2-chloro-2,2-difluoroacetamide 
• 1588-39-2 chloro-difluoro-thioacetyl fluoride 
• 383-62-0 ethyl 2-chloro-2,2-difluoroacetate 
• 7664-39-3 hydrogen fluoride 
• 545-06-2 trichloroacetonitrile 

Downstream Products

• 13337-86-5 2,4,6-tris-(chloro-difluoro-methyl)-2-(4-chloro-phenyl)-1,2-dihydro-[1,3,5]triazine 
• 13337-85-4 2,4-diphenyl-2,6-bis(chlorodifluoromethyl)-1,2-dihydrotriazine 
• 454-58-0 2-Difluorchlormethyl-pyridin 
• 13337-82-1 α-Chlor-α,α-difluor-acetophenon-imin 
• 13337-83-2 2,4,6-tris-(chloro-difluoro-methyl)-2-phenyl-1,2-dihydro-[1,3,5]triazine 
• 14727-31-2 2,4,6-tris-(chloro-difluoro-methyl)-2-(3,4-dichloro-phenyl)-1,2-dihydro-[1,3,5]triazine 
• 353-85-5 trifluoroacetonitrile 

Relevant articles and documents

Activated dimethyl sulfoxide dehydration of amide and its application to one-pot preparation of benzyl-type perfluoroimidates

Various types of primary amides were treated under an activated dimethyl sulfoxide (DMSO) species, (COCl)2-DMSO and Et3N, as a dehydrating agent to obtain nitriles in excellent yield. This dehydration system was extended to a one-pot preparation of perfluoroimidates via volatile perfluoronitriles from perfluoroamides. Fifteen benzyl-type perfluoroimidates can be prepared in 70-90% yield as more stable imidates than the trichloro analogue. MPM- and DMPM-perfluoroimidates can be used to protect alcohols in place of the trichloroacetimidate with excellent chemical properties and in comparable yields.