3-bromo-6-chloro-2-fluorobenzoic acid

Base Information

• Chemical Name: 3-bromo-6-chloro-2-fluorobenzoic acid
• CAS No.: 702640-51-5
• Molecular Formula: C₇H₃BrClFO₂
• Molecular Weight: 253.455
• Hs Code.: 2916310090
• Mol file: 702640-51-5.mol

Synonyms:3-bromo-6-chloro-2-fluorobenzoic acid

Chemical Property of 3-bromo-6-chloro-2-fluorobenzoic acid

Chemical Property:

• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

3-Bromo-6-chloro-2-fluorobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-bromo-6-chloro-2-fluorobenzoic acid

There total 2 articles about 3-bromo-6-chloro-2-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.4%

carbon dioxide (124-38-9,18923-20-1) + 1-bromo-4-chloro-2-fluorobenzene (1996-29-8) → 3-bromo-6-chloro-2-fluorobenzoic acid (702640-51-5)

Guidance literature:

1-bromo-4-chloro-2-fluorobenzene; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

carbon dioxide; In tetrahydrofuran; at 20 ℃;

Reference yield:

C6H2BrClFLi + carbon dioxide (124-38-9,18923-20-1) → 3-bromo-6-chloro-2-fluorobenzoic acid (702640-51-5)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -70 - 20 ℃;

Reference yield: 71.6%

3-bromo-6-chloro-2-fluorobenzoic acid (702640-51-5) + N-methyl-1,2-phenylenediamine (4760-34-3) → 3-bromo-6-chloro-2-fluoro-N-(2-(methylamino)phenyl)benzamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

carbon dioxide

1-bromo-4-chloro-2-fluorobenzene

Refernces

• 1、 -. "SUBSTITUTED AMINO PHENYLACETIC ACIDS, DERIVATIVES THEREOF, THEIR PREPARATION AND THEIR USE AS CYCLOOXYGENASE 2 (COX-2) INHIBITORS". Page 34-35. . Retrieved 2008/06/13.