N-(3-chloro-5-(((1-(3'-chloro-[1,1'-biphenyl]-3-yl)-4-cyano-3-methyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

Base Information

• Chemical Name: N-(3-chloro-5-(((1-(3'-chloro-[1,1'-biphenyl]-3-yl)-4-cyano-3-methyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide
• CAS No.: 1448812-61-0
• Molecular Formula: C₂₇H₂₃Cl₂N₅O₂
• Molecular Weight: 520.418
• Mol file: 1448812-61-0.mol

Synonyms:N-(3-chloro-5-(((1-(3'-chloro-[1,1'-biphenyl]-3-yl)-4-cyano-3-methyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

Chemical Property of N-(3-chloro-5-(((1-(3'-chloro-[1,1'-biphenyl]-3-yl)-4-cyano-3-methyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-chloro-5-(((1-(3'-chloro-[1,1'-biphenyl]-3-yl)-4-cyano-3-methyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

There total 3 articles about N-(3-chloro-5-(((1-(3'-chloro-[1,1'-biphenyl]-3-yl)-4-cyano-3-methyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(5-(((1-(3-bromophenyl)-4-cyano-3-methyl-1H-pyrazol-5-yl)amino)methyl)-3-chloro-2-hydroxyphenyl)propionamide (1448812-40-5) + 3-chlorophenylboronic acid (63503-60-6) → N-(3-chloro-5-(((1-(3'-chloro-[1,1'-biphenyl]-3-yl)-4-cyano-3-methyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide (1448812-61-0)

Guidance literature:

With tricalcium phosphate hydrate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; at 100 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

N-(3-chloro-2-hydroxyphenyl)propionamide (221291-87-8) → N-(3-chloro-5-(((1-(3'-chloro-[1,1'-biphenyl]-3-yl)-4-cyano-3-methyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide (1448812-61-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hexamethylenetetramine / 130 °C / Inert atmosphere

2.1: toluene / 0.5 h / Reflux

2.2: 0.17 h / Reflux

2.3: 1 h / 0 - 20 °C

3.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; tricalcium phosphate hydrate / water; 1,4-dioxane / 0.17 h / 100 °C / Microwave irradiation

With tricalcium phosphate hydrate; hexamethylenetetramine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; toluene;

Reference yield:

N-(3-chloro-5-formyl-2-hydroxyphenyl)propionamide (1448812-08-5) → N-(3-chloro-5-(((1-(3'-chloro-[1,1'-biphenyl]-3-yl)-4-cyano-3-methyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide (1448812-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene / 0.5 h / Reflux

1.2: 0.17 h / Reflux

1.3: 1 h / 0 - 20 °C

2.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; tricalcium phosphate hydrate / water; 1,4-dioxane / 0.17 h / 100 °C / Microwave irradiation

With tricalcium phosphate hydrate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; toluene;

upstream raw materials:

N-(3-chloro-2-hydroxyphenyl)propionamide

N-(5-(((1-(3-bromophenyl)-4-cyano-3-methyl-1H-pyrazol-5-yl)amino)methyl)-3-chloro-2-hydroxyphenyl)propionamide

3-chlorophenylboronic acid

N-(3-chloro-5-formyl-2-hydroxyphenyl)propionamide