TERT-BUTYL 3-BENZYLOXY-4-BROMOBENZOATE

Base Information

• Chemical Name: TERT-BUTYL 3-BENZYLOXY-4-BROMOBENZOATE
• CAS No.: 247186-50-1
• Molecular Formula: C18H19BrO3
• Molecular Weight: 363.24566
• Hs Code.: 2918990090
• Mol file: 247186-50-1.mol

Synonyms:TERT-BUTYL 3-BENZYLOXY-4-BROMOBENZOATE;tert-Butyl 3-benzyloxy-4-bromobenzoate 98%

Chemical Property of TERT-BUTYL 3-BENZYLOXY-4-BROMOBENZOATE

Chemical Property:

• Vapor Pressure: 4.7E-08mmHg at 25°C
• Refractive Index: 1.567
• Boiling Point: 443.3 °C at 760 mmHg
• Flash Point: 221.9 °C
• PSA: 35.53000
• Density: 1.307 g/cm³
• LogP: 4.98340
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 3-benzyloxy-4-bromobenzoate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of TERT-BUTYL 3-BENZYLOXY-4-BROMOBENZOATE

There total 4 articles about TERT-BUTYL 3-BENZYLOXY-4-BROMOBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-bromo-3-benzyloxybenzoic acid (17054-27-2) + tert-butyl alcohol (75-65-0) → 4-bromo-3-benzyloxybenzoic acid 1,1-dimethylethyl ester (247186-50-1)

Guidance literature:

4-bromo-3-benzyloxybenzoic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 40 ℃; for 3h;

tert-butyl alcohol; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 55 ℃; for 40h; Further stages.;

DOI:10.1021/jm020018f

Reference yield:

4-bromo-3-hydroxybenzoic acid (14348-38-0) → 4-bromo-3-benzyloxybenzoic acid 1,1-dimethylethyl ester (247186-50-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 100 percent / K₂CO₃ / dimethylformamide / 72 h / 20 °C

2.1: 97 percent / aq. NaOH / methanol / 4 h / 60 °C

3.1: CDI / dimethylformamide / 3 h / 40 °C

3.2: 82 percent / DBU / dimethylformamide / 40 h / 55 °C

With sodium hydroxide; potassium carbonate; 1,1'-carbonyldiimidazole; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm020018f

Reference yield:

3-Benzyloxy-4-brombenzoesaeure-benzylester (124318-23-6) → 4-bromo-3-benzyloxybenzoic acid 1,1-dimethylethyl ester (247186-50-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 97 percent / aq. NaOH / methanol / 4 h / 60 °C

2.1: CDI / dimethylformamide / 3 h / 40 °C

2.2: 82 percent / DBU / dimethylformamide / 40 h / 55 °C

With sodium hydroxide; 1,1'-carbonyldiimidazole; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm020018f

upstream raw materials:

4-bromo-3-benzyloxybenzoic acid

tert-butyl alcohol

4-bromo-3-hydroxybenzoic acid

3-Benzyloxy-4-brombenzoesaeure-benzylester

Downstream raw materials:

4-tert-butyloxycarbonyl-2-benzyloxybenzoic acid

3-benzyloxy-4-[6-benzyloxy-2-(1,3-dioxan-2-yl)benzoyl]benzoic acid

1,1-dimethylethyl 3-benzyloxy-4-[6-benzyloxy-2-(1,3-dioxan-2-yl)benzoyl]benzoate

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