1-(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)benzoyl)pyrrolidine-2-carboxylic acid

Base Information

Chemical Name:1-(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)benzoyl)pyrrolidine-2-carboxylic acid
CAS No.:1456928-94-1
Molecular Formula:C₂₅H₂₁N₃O₄
Molecular Weight:427.459
Hs Code.:

Synonyms:1-(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)benzoyl)pyrrolidine-2-carboxylic acid

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Chemical Property of 1-(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)benzoyl)pyrrolidine-2-carboxylic acid

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Technology Process of 1-(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)benzoyl)pyrrolidine-2-carboxylic acid

There total 8 articles about 1-(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)benzoyl)pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1456928-92-9
methyl 1-(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)(benzoyl)(pyrrolidine))-2-carboxylate

: 1456928-94-1
1-(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)benzoyl)pyrrolidine-2-carboxylic acid

Guidance literature:: With lithium hydroxide; In methanol; water; at 30 ℃; for 4h;
DOI:10.2174/1570180811310070010

Reference yield:

: 53857-57-1
5-bromo-1H-indazole

: 1456928-94-1
1-(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)benzoyl)pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 3 h / 0 °C / Inert atmosphere

2: toluene-4-sulfonic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: water; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

4: water; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

5: lithium hydroxide; methanol / water / 4 h / 30 °C

6: HATU / N,N-dimethyl-formamide / 0.17 h / 25 °C / Inert atmosphere

7: hydrogenchloride / methanol / 1 h / 0 °C

8: lithium hydroxide / water; methanol / 4 h / 30 °C

With hydrogenchloride; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; iodine; sodium carbonate; toluene-4-sulfonic acid; HATU; potassium hydroxide; lithium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; 3: |Suzuki Coupling / 4: |Suzuki Coupling;
DOI:10.2174/1570180811310070010

Reference yield:

: 1456928-96-3
ethyl 4-(3-(4-hydroxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl) benzoate

: 1456928-94-1
1-(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)benzoyl)pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide; methanol / water / 4 h / 30 °C

2: HATU / N,N-dimethyl-formamide / 0.17 h / 25 °C / Inert atmosphere

3: hydrogenchloride / methanol / 1 h / 0 °C

4: lithium hydroxide / water; methanol / 4 h / 30 °C

With hydrogenchloride; methanol; HATU; lithium hydroxide; In methanol; water; N,N-dimethyl-formamide;
DOI:10.2174/1570180811310070010