methyl 1-(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)(benzoyl)(pyrrolidine))-2-carboxylate

Base Information

Chemical Name:methyl 1-(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)(benzoyl)(pyrrolidine))-2-carboxylate
CAS No.:1456928-92-9
Molecular Formula:C₂₆H₂₃N₃O₄
Molecular Weight:441.486
Hs Code.:

Synonyms:methyl 1-(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)(benzoyl)(pyrrolidine))-2-carboxylate

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Chemical Property of methyl 1-(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)(benzoyl)(pyrrolidine))-2-carboxylate

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Technology Process of methyl 1-(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)(benzoyl)(pyrrolidine))-2-carboxylate

There total 7 articles about methyl 1-(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)(benzoyl)(pyrrolidine))-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: C₃₁H₃₁N₃O₅

: 1456928-92-9
methyl 1-(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)(benzoyl)(pyrrolidine))-2-carboxylate

Guidance literature:: With hydrogenchloride; In methanol; at 0 ℃; for 1h;
DOI:10.2174/1570180811310070010

Reference yield:

: 53857-57-1
5-bromo-1H-indazole

: 1456928-92-9
methyl 1-(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)(benzoyl)(pyrrolidine))-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 3 h / 0 °C / Inert atmosphere

2: toluene-4-sulfonic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: water; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

4: water; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

5: lithium hydroxide; methanol / water / 4 h / 30 °C

6: HATU / N,N-dimethyl-formamide / 0.17 h / 25 °C / Inert atmosphere

7: hydrogenchloride / methanol / 1 h / 0 °C

With hydrogenchloride; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; iodine; sodium carbonate; toluene-4-sulfonic acid; HATU; potassium hydroxide; lithium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; 3: |Suzuki Coupling / 4: |Suzuki Coupling;
DOI:10.2174/1570180811310070010

Reference yield:

: 1456928-97-4
4-(3-(4-hydroxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl) benzoic acid

: 1456928-92-9
methyl 1-(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)(benzoyl)(pyrrolidine))-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: HATU / N,N-dimethyl-formamide / 0.17 h / 25 °C / Inert atmosphere

2: hydrogenchloride / methanol / 1 h / 0 °C

With hydrogenchloride; HATU; In methanol; N,N-dimethyl-formamide;
DOI:10.2174/1570180811310070010