methyl 4-((1S,2R)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-hydroxy-3-((S)-6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl)-3-oxopropan-2-yloxy)-3,5-dimethoxybenzoate

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Chemical Name:methyl 4-((1S,2R)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-hydroxy-3-((S)-6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl)-3-oxopropan-2-yloxy)-3,5-dimethoxybenzoate
CAS No.:1404575-40-1
Molecular Formula:C₄₀H₄₄N₂O₁₀
Molecular Weight:712.797
Hs Code.:

methyl 4-((1S,2R)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-hydroxy-3-((S)-6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl)-3-oxopropan-2-yloxy)-3,5-dimethoxybenzoate

Synonyms:methyl 4-((1S,2R)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-hydroxy-3-((S)-6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl)-3-oxopropan-2-yloxy)-3,5-dimethoxybenzoate

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Chemical Property of methyl 4-((1S,2R)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-hydroxy-3-((S)-6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl)-3-oxopropan-2-yloxy)-3,5-dimethoxybenzoate

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Technology Process of methyl 4-((1S,2R)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-hydroxy-3-((S)-6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl)-3-oxopropan-2-yloxy)-3,5-dimethoxybenzoate

There total 14 articles about methyl 4-((1S,2R)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-hydroxy-3-((S)-6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl)-3-oxopropan-2-yloxy)-3,5-dimethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 1404575-39-8
(S)-methyl 4-[2-{6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl}-2-oxoethoxy]-3,5-dimethoxybenzoate

: 1404575-40-1
methyl 4-((1S,2R)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-hydroxy-3-((S)-6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl)-3-oxopropan-2-yloxy)-3,5-dimethoxybenzoate

: C₄₀H₄₄N₂O₁₀

Guidance literature:: (S)-methyl 4-[2-{6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl}-2-oxoethoxy]-3,5-dimethoxybenzoate; With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 - 0 ℃; for 2h;

3-methoxy-4-(phenylmethoxy)benzaldehyde; In dichloromethane; at -78 ℃; for 1h;
DOI:10.1021/ol302653g

Reference yield:

: 1404573-71-2
(S)-4-methyl-N¹-phenylpentane-1,3-diamine

: 1404575-40-1
methyl 4-((1S,2R)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-hydroxy-3-((S)-6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl)-3-oxopropan-2-yloxy)-3,5-dimethoxybenzoate

: C₄₀H₄₄N₂O₁₀

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / water; toluene / 1 h / 0 °C / Inert atmosphere

1.2: 1 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 2 h / -78 - 0 °C

3.1: titanium tetrachloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / -78 - 0 °C

3.2: 1 h / -78 °C

With n-butyllithium; titanium tetrachloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; water; toluene;
DOI:10.1021/ol302653g

Reference yield:

: 15790-86-0
ethyl-4-methyl-2-(E)-penteneoate

: 1404575-40-1
methyl 4-((1S,2R)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-hydroxy-3-((S)-6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl)-3-oxopropan-2-yloxy)-3,5-dimethoxybenzoate

: C₄₀H₄₄N₂O₁₀

Guidance literature:: Multi-step reaction with 8 steps

1.1: hexane; tetrahydrofuran / 2.5 h / -78 °C

2.1: potassium hydroxide / water; ethanol / 7 h / Reflux

3.1: triethylamine; chloroformic acid ethyl ester / dichloromethane / 1 h / 0 °C / Inert atmosphere

3.2: 3 h / 20 °C

4.1: hydrogen; 10 wt% Pd(OH)2 on carbon / methanol; water; acetic acid / 3 h / 20 °C / 3800.26 Torr

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Reflux

6.1: potassium carbonate / water; toluene / 1 h / 0 °C / Inert atmosphere

6.2: 1 h / 20 °C

7.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

7.2: 2 h / -78 - 0 °C

8.1: titanium tetrachloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / -78 - 0 °C

8.2: 1 h / -78 °C

With lithium aluminium tetrahydride; n-butyllithium; 10 wt% Pd(OH)2 on carbon; hydrogen; chloroformic acid ethyl ester; titanium tetrachloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; acetic acid; toluene; 1.1: |Michael Addition;
DOI:10.1021/ol302653g