Technology Process of 3-(2-((2-chloro-5-(trifluoromethyl)phenyl)ethynyl)phenyl)-1-(4-methoxyphenyl)prop-2-yn-1-one
There total 7 articles about 3-(2-((2-chloro-5-(trifluoromethyl)phenyl)ethynyl)phenyl)-1-(4-methoxyphenyl)prop-2-yn-1-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridinium chlorochromate;
In
dichloromethane;
at 20 ℃;
for 24h;
Molecular sieve;
DOI:10.1021/jo501015x
- Guidance literature:
-
Multi-step reaction with 5 steps
1: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere; Sealed tube
2: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 18 h / 80 °C / Inert atmosphere; Sealed tube
3: tetrabutyl ammonium fluoride / isopropyl alcohol; tetrahydrofuran / 1 h / -89 °C / Inert atmosphere
4: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / 20 h / 80 °C / Inert atmosphere; Sealed tube
5: pyridinium chlorochromate / dichloromethane / 24 h / 20 °C / Molecular sieve
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; triethylamine; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane; isopropyl alcohol;
1: |Sonogashira Cross-Coupling / 2: |Sonogashira Cross-Coupling / 4: |Sonogashira Cross-Coupling;
DOI:10.1021/jo501015x
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: n-butyllithium / hexane; isopropyl alcohol; tetrahydrofuran / 0.67 h / -89 °C / Inert atmosphere
1.2: 4 h / 20 °C / Inert atmosphere
2.1: potassium carbonate / methanol / 18 h / 20 °C
3.1: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere; Sealed tube
4.1: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 18 h / 80 °C / Inert atmosphere; Sealed tube
5.1: tetrabutyl ammonium fluoride / isopropyl alcohol; tetrahydrofuran / 1 h / -89 °C / Inert atmosphere
6.1: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / 20 h / 80 °C / Inert atmosphere; Sealed tube
7.1: pyridinium chlorochromate / dichloromethane / 24 h / 20 °C / Molecular sieve
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; hexane; dichloromethane; isopropyl alcohol;
3.1: |Sonogashira Cross-Coupling / 4.1: |Sonogashira Cross-Coupling / 6.1: |Sonogashira Cross-Coupling;
DOI:10.1021/jo501015x