4-(7-trifluoromethylquinolin-4-ylamino)benzoic acid hydrazide

Base Information

• Chemical Name: 4-(7-trifluoromethylquinolin-4-ylamino)benzoic acid hydrazide
• CAS No.: 864832-54-2
• Molecular Formula: C₁₇H₁₃F₃N₄O
• Molecular Weight: 346.312
• Mol file: 864832-54-2.mol

Synonyms:4-(7-trifluoromethylquinolin-4-ylamino)benzoic acid hydrazide

Chemical Property of 4-(7-trifluoromethylquinolin-4-ylamino)benzoic acid hydrazide

Chemical Property:

Purity/Quality:

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Technology Process of 4-(7-trifluoromethylquinolin-4-ylamino)benzoic acid hydrazide

There total 2 articles about 4-(7-trifluoromethylquinolin-4-ylamino)benzoic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(7-Trifluoromethyl-quinolin-4-ylamino)-benzoyl chloride (71916-60-4) → 4-(7-trifluoromethylquinolin-4-ylamino)benzoic acid hydrazide (864832-54-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 6h; Heating;

DOI:10.1016/j.bmc.2005.05.053

Reference yield:

4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoic acid (71916-45-5) → 4-(7-trifluoromethylquinolin-4-ylamino)benzoic acid hydrazide (864832-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 4 h / Heating

2: hydrazine hydrate / ethanol / 6 h / Heating

With thionyl chloride; hydrazine hydrate; In ethanol;

DOI:10.1016/j.bmc.2005.05.053

Reference yield: 80.0%

4-(7-trifluoromethylquinolin-4-ylamino)benzoic acid hydrazide (864832-54-2) + 2-chloropropionyl chloride (625-36-5) → 4-(7-trifluoromethyl-quinolin-4-ylamino)-benzoic acid N'-(3-chloro-propionyl)-hydrazide (864832-57-5)

Guidance literature:

With triethylamine; In benzene; for 10h; Heating;

DOI:10.1016/j.bmc.2005.05.053

upstream raw materials:

4-(7-Trifluoromethyl-quinolin-4-ylamino)-benzoyl chloride

4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoic acid

Downstream raw materials:

4-(7-trifluoromethyl-quinolin-4-ylamino)-benzoic acid N'-(3-chloro-propionyl)-hydrazide