N-{3-[1-(1-acetylpiperidin-4-yl)-4-(2-tert-butylaminopyridin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide

Base Information

Chemical Name:N-{3-[1-(1-acetylpiperidin-4-yl)-4-(2-tert-butylaminopyridin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide
CAS No.:1357588-00-1
Molecular Formula:C₃₃H₃₇F₃N₆O₄S
Molecular Weight:670.756
Hs Code.:

N-{3-[1-(1-acetylpiperidin-4-yl)-4-(2-tert-butylaminopyridin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide

Synonyms:N-{3-[1-(1-acetylpiperidin-4-yl)-4-(2-tert-butylaminopyridin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide

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Chemical Property of N-{3-[1-(1-acetylpiperidin-4-yl)-4-(2-tert-butylaminopyridin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide

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Technology Process of N-{3-[1-(1-acetylpiperidin-4-yl)-4-(2-tert-butylaminopyridin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide

There total 12 articles about N-{3-[1-(1-acetylpiperidin-4-yl)-4-(2-tert-butylaminopyridin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1357587-98-4
N-{3-[4-(2-tert-butylaminopyridin-4-yl)-1-piperidin-4-yl-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide

: 75-36-5
acetyl chloride

: 1357588-00-1
N-{3-[1-(1-acetylpiperidin-4-yl)-4-(2-tert-butylaminopyridin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 58534-95-5
3-bromo-2-fluorobenzenamine

: 1357588-00-1
N-{3-[1-(1-acetylpiperidin-4-yl)-4-(2-tert-butylaminopyridin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 11 steps

1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.17 h / 0 - 20 °C

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

4: toluene-4-sulfonic acid / methanol / 1 h / 20 °C

5: N-Bromosuccinimide / dichloromethane / 1.5 h / 20 °C

6: caesium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

7: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

8: 3-chloro-benzenecarboperoxoic acid / 20 °C

9: tosylanhydride / α,α,α-trifluorotoluene / 0 °C

10: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

11: triethylamine / dichloromethane / 1 h / 20 °C

With pyridine; hydrogenchloride; N-Bromosuccinimide; caesium carbonate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; dichloromethane; α,α,α-trifluorotoluene; water; N,N-dimethyl-formamide;

Reference yield:

: 26120-86-5
2,5-difluorobenzenesulfonyl chloride

: 1357588-00-1
N-{3-[1-(1-acetylpiperidin-4-yl)-4-(2-tert-butylaminopyridin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 11 steps

1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.17 h / 0 - 20 °C

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

4: toluene-4-sulfonic acid / methanol / 1 h / 20 °C

5: N-Bromosuccinimide / dichloromethane / 1.5 h / 20 °C

6: caesium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

7: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

8: 3-chloro-benzenecarboperoxoic acid / 20 °C

9: tosylanhydride / α,α,α-trifluorotoluene / 0 °C

10: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

11: triethylamine / dichloromethane / 1 h / 20 °C

With pyridine; hydrogenchloride; N-Bromosuccinimide; caesium carbonate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; dichloromethane; α,α,α-trifluorotoluene; water; N,N-dimethyl-formamide;