Diethyl 2-(4-cyanophenyl)-2-hydroxy-1-(trimethylsiloxy)-1-phenylethanephosphonate

Base Information

Chemical Name:Diethyl 2-(4-cyanophenyl)-2-hydroxy-1-(trimethylsiloxy)-1-phenylethanephosphonate
CAS No.:74562-17-7
Molecular Formula:C₂₂H₃₀NO₅PSi
Molecular Weight:447.543
Hs Code.:

Synonyms:Diethyl 2-(4-cyanophenyl)-2-hydroxy-1-(trimethylsiloxy)-1-phenylethanephosphonate

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Chemical Property of Diethyl 2-(4-cyanophenyl)-2-hydroxy-1-(trimethylsiloxy)-1-phenylethanephosphonate

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Technology Process of Diethyl 2-(4-cyanophenyl)-2-hydroxy-1-(trimethylsiloxy)-1-phenylethanephosphonate

There total 2 articles about Diethyl 2-(4-cyanophenyl)-2-hydroxy-1-(trimethylsiloxy)-1-phenylethanephosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 31675-43-1
diethyl 1-phenyl-1-(trimethylsiloxy)methanephosphonate

: 105-07-7
4-cyanobenzaldehyde

: 74562-17-7
Diethyl 2-(4-cyanophenyl)-2-hydroxy-1-(trimethylsiloxy)-1-phenylethanephosphonate

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -100 - -60 ℃; for 0.166667h;
DOI:10.1021/jo01308a009

Reference yield:

: 100-52-7
benzaldehyde

: 74562-17-7
Diethyl 2-(4-cyanophenyl)-2-hydroxy-1-(trimethylsiloxy)-1-phenylethanephosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / 4 h / Heating

2: 82 percent / Diisopropylamine, n-BuLi / tetrahydrofuran / 0.17 h / -100 - -60 °C

With n-butyllithium; diisopropylamine; In tetrahydrofuran;
DOI:10.1021/jo01308a009