(1'R,3R,6S)-{{6-{2'-{[dimethyl(1,1,2-trimethylpropyl)silyl]oxy}-1'-methylethyl}-3-methylcyclohex-1-en-1-yl}oxy}trimethylsylane

Base Information

Chemical Name:(1'R,3R,6S)-{{6-{2'-{[dimethyl(1,1,2-trimethylpropyl)silyl]oxy}-1'-methylethyl}-3-methylcyclohex-1-en-1-yl}oxy}trimethylsylane
CAS No.:252289-40-0
Molecular Formula:C₂₁H₄₄O₂Si₂
Molecular Weight:384.75
Hs Code.:

Synonyms:(1'R,3R,6S)-{{6-{2'-{[dimethyl(1,1,2-trimethylpropyl)silyl]oxy}-1'-methylethyl}-3-methylcyclohex-1-en-1-yl}oxy}trimethylsylane

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Chemical Property of (1'R,3R,6S)-{{6-{2'-{[dimethyl(1,1,2-trimethylpropyl)silyl]oxy}-1'-methylethyl}-3-methylcyclohex-1-en-1-yl}oxy}trimethylsylane

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Technology Process of (1'R,3R,6S)-{{6-{2'-{[dimethyl(1,1,2-trimethylpropyl)silyl]oxy}-1'-methylethyl}-3-methylcyclohex-1-en-1-yl}oxy}trimethylsylane

There total 4 articles about (1'R,3R,6S)-{{6-{2'-{[dimethyl(1,1,2-trimethylpropyl)silyl]oxy}-1'-methylethyl}-3-methylcyclohex-1-en-1-yl}oxy}trimethylsylane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 75-77-4
chloro-trimethyl-silane

: 252289-39-7
(1'R,2S,5R)-2-{2'-{[dimethyl(1,1,2-trimethylpropyl)silyl]oxy}-1'-methylethyl}-5-methylcyclohexanone

: 252289-40-0
(1'R,3R,6S)-{{6-{2'-{[dimethyl(1,1,2-trimethylpropyl)silyl]oxy}-1'-methylethyl}-3-methylcyclohex-1-en-1-yl}oxy}trimethylsylane

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h;
DOI:10.1002/(SICI)1522-2675(19991006)82:10<1610::AID-HLCA1610>3.0.CO;2-T

Reference yield:

: 13834-07-6
(1R,3R,4S,8R)-9-hydroxy-p-menthol

: 252289-40-0
(1'R,3R,6S)-{{6-{2'-{[dimethyl(1,1,2-trimethylpropyl)silyl]oxy}-1'-methylethyl}-3-methylcyclohex-1-en-1-yl}oxy}trimethylsylane

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / 1H-imidazole / dimethylformamide / 15 h / 0 - 20 °C

2: 62 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 3 h / -79 °C

3: 100 percent / BuLi; (i-Pr)2NH / hexane; tetrahydrofuran / 1 h / -78 °C

With 1H-imidazole; n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triethylamine; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Oxidation / 3: Etherification;
DOI:10.1002/(SICI)1522-2675(19991006)82:10<1610::AID-HLCA1610>3.0.CO;2-T

Reference yield:

: 7786-67-6,18674-65-2,20549-46-6,21290-09-5,29141-10-4,50373-36-9,59905-53-2,59905-54-3,96612-21-4,104870-56-6,121468-66-4,122517-60-6,122517-61-7,144541-38-8,89-79-2
isopulegol

: 252289-40-0
(1'R,3R,6S)-{{6-{2'-{[dimethyl(1,1,2-trimethylpropyl)silyl]oxy}-1'-methylethyl}-3-methylcyclohex-1-en-1-yl}oxy}trimethylsylane

Guidance literature:: Multi-step reaction with 4 steps

1.1: B₂H₆ / tetrahydrofuran / 2 h / 0 - 20 °C

1.2: NaOH; H₂O₂ / 0.5 h / Heating

2.1: 91 percent / 1H-imidazole / dimethylformamide / 15 h / 0 - 20 °C

3.1: 62 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 3 h / -79 °C

4.1: 100 percent / BuLi; (i-Pr)2NH / hexane; tetrahydrofuran / 1 h / -78 °C

With 1H-imidazole; n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triethylamine; diisopropylamine; diborane; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 1.1: hydroboration / 1.2: Oxidation / 2.1: Substitution / 3.1: Oxidation / 4.1: Etherification;
DOI:10.1002/(SICI)1522-2675(19991006)82:10<1610::AID-HLCA1610>3.0.CO;2-T