3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-1-ol

Base Information

• Chemical Name: 3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-1-ol
• CAS No.: 1000802-50-5
• Molecular Formula: C₁₂H₂₁BN₂O₃
• Molecular Weight: 252.121
• Mol file: 1000802-50-5.mol

Synonyms:3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propan-1-ol

Chemical Property of 3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-1-ol

Chemical Property:

• Boiling Point: 400.6±25.0 °C(Predicted)
• PKA: 14.91±0.10(Predicted)
• Density: 1.11±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

3-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-1-ol 97.0% ^*data from reagent suppliers

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Technology Process of 3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-1-ol

There total 3 articles about 3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(4-bromo-1H-pyrazol-1-yl)propan-1-ol (925180-06-9) + bis(pinacol)diborane (73183-34-3) → 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propan-1-ol (1000802-50-5)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 120 ℃; for 2h; Microwave irradiation;

Reference yield: 99.0%

1-[3-(benzyloxy)propyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (1309960-92-6) → 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propan-1-ol (1000802-50-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol;

Reference yield:

pyrazole-4-boronic acid pinacol ester (269410-08-4) → 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propan-1-ol (1000802-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

2: hydrogen; palladium 10% on activated carbon / ethanol

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

3-(4-bromo-1H-pyrazol-1-yl)propan-1-ol

bis(pinacol)diborane

pyrazole-4-boronic acid pinacol ester

1-[3-(benzyloxy)propyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Downstream raw materials:

2-amino-N,N-diethyl-5-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]benzamide

diethyl (4-{[4-({5-fluoro-4-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-(methylcarbamoyl)phenyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate

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