1-[3-(benzyloxy)propyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Base Information

Chemical Name:1-[3-(benzyloxy)propyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CAS No.:1309960-92-6
Molecular Formula:C₁₉H₂₇BN₂O₃
Molecular Weight:342.246
Hs Code.:

Synonyms:1-[3-(benzyloxy)propyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Suppliers and Price of 1-[3-(benzyloxy)propyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[3-(benzyloxy)propyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Chemical Property:

Purity/Quality:: 98%+ ^*data from raw suppliers

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Technology Process of 1-[3-(benzyloxy)propyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

There total 5 articles about 1-[3-(benzyloxy)propyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 269410-08-4
pyrazole-4-boronic acid pinacol ester

: 54314-84-0
1-[(3-bromopropoxy)methyl]-benzene

: 1309960-92-6
1-[3-(benzyloxy)propyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

: 269410-08-4
pyrazole-4-boronic acid pinacol ester

: 5375-00-8
3-benzyloxypropyl iodide

: 1309960-92-6
1-[3-(benzyloxy)propyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm200112k

Reference yield:

: 4799-68-2
3-benzyloxypropan-1-ol

: 1309960-92-6
1-[3-(benzyloxy)propyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethyl acetate / 1 h / 20 °C / Inert atmosphere

2: sodium iodide / acetone / 60 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C / Inert atmosphere

With potassium carbonate; triethylamine; sodium iodide; In ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm200112k