ethyl 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylate

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Chemical Name:ethyl 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylate
CAS No.:1314217-86-1
Molecular Formula:C₂₀H₁₈F₃NO₄
Molecular Weight:393.362
Hs Code.:

Synonyms:ethyl 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylate

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Chemical Property of ethyl 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylate

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Technology Process of ethyl 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylate

There total 6 articles about ethyl 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 625-35-4,3488-22-0,10487-71-5
trans-chrotonyl chloride

: 1314217-84-9
ethyl 5-{[(4-trifluoromethoxybenzyl)amino]methyl}-furan-3-carboxylate hydrochloride

: 1314217-86-1
ethyl 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylate

Guidance literature:: trans-chrotonyl chloride; ethyl 5-{[(4-trifluoromethoxybenzyl)amino]methyl}-furan-3-carboxylate hydrochloride; With N-ethyl-N,N-diisopropylamine; In toluene; at 20 ℃;

With methanesulfonic acid; In toluene; for 12h; Reflux;

Reference yield:

: C₁₆H₁₄F₃NO₄

: 1314217-86-1
ethyl 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / toluene / -5 °C

2.1: N-ethyl-N,N-diisopropylamine / toluene / 20 °C

2.2: 12 h / Reflux

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In toluene; 2.1: Diels-Alder Reaction;

Reference yield:

: 614-98-2
ethyl 3-furancarboxylate

: 1314217-86-1
ethyl 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: trichlorophosphate / 60 °C

2: toluene

3: sodium tetrahydroborate / toluene / -5 °C

4: hydrogenchloride / ethanol; water; toluene / 55 °C

5: N-ethyl-N,N-diisopropylamine / toluene / 12 h / Reflux

6: methanesulfonic acid / toluene / 24 h / Reflux

With hydrogenchloride; sodium tetrahydroborate; methanesulfonic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In ethanol; water; toluene; 5: Diels-Alder reaction;
DOI:10.1021/op300002f