(2R,5R)-2-methyl-5-(toluene-4-sulfonyloxymethyl)piperidine-1-carboxylic cid tert-butyl ester

Base Information

Chemical Name:(2R,5R)-2-methyl-5-(toluene-4-sulfonyloxymethyl)piperidine-1-carboxylic cid tert-butyl ester
CAS No.:1088994-12-0
Molecular Formula:C₁₉H₂₉NO₅S
Molecular Weight:383.509
Hs Code.:

Synonyms:(2R,5R)-2-methyl-5-(toluene-4-sulfonyloxymethyl)piperidine-1-carboxylic cid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,5R)-2-methyl-5-(toluene-4-sulfonyloxymethyl)piperidine-1-carboxylic cid tert-butyl ester

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Technology Process of (2R,5R)-2-methyl-5-(toluene-4-sulfonyloxymethyl)piperidine-1-carboxylic cid tert-butyl ester

There total 4 articles about (2R,5R)-2-methyl-5-(toluene-4-sulfonyloxymethyl)piperidine-1-carboxylic cid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1009376-93-5
(2R,5R)-tert-butyl 5-(hydroxymethyl)-2-methylpiperidine-1-carboxylate

: 98-59-9
p-toluenesulfonyl chloride

: 1088994-12-0
(2R,5R)-2-methyl-5-(toluene-4-sulfonyloxymethyl)piperidine-1-carboxylic cid tert-butyl ester

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 19h;

Reference yield:

: 1088994-07-3
((3R)-6-methylpiperidin-3-yl)-methanol

: 1088994-12-0
(2R,5R)-2-methyl-5-(toluene-4-sulfonyloxymethyl)piperidine-1-carboxylic cid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 1.75 h / 20 °C / Large scale

2: triethylamine / dichloromethane / 3 h / Large scale

3: pyridine / 18 h / 10 - 20 °C

With pyridine; triethylamine; In tetrahydrofuran; dichloromethane; 3: |Mitsunobu Displacement;
DOI:10.1021/op3002678

Reference yield:

: 1088994-09-5
((3R,6R)-6-methylpiperidin-3-yl)methanol (1S)-(+)-10-camphorsulfonic acid

: 1088994-12-0
(2R,5R)-2-methyl-5-(toluene-4-sulfonyloxymethyl)piperidine-1-carboxylic cid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / Large scale

2: pyridine / 18 h / 10 - 20 °C

With pyridine; triethylamine; In dichloromethane; 2: |Mitsunobu Displacement;
DOI:10.1021/op3002678