((3R,6R)-6-methylpiperidin-3-yl)methanol (1S)-(+)-10-camphorsulfonic acid

Base Information

Chemical Name:((3R,6R)-6-methylpiperidin-3-yl)methanol (1S)-(+)-10-camphorsulfonic acid
CAS No.:1088994-09-5
Molecular Formula:C₇H₁₅NO*C₁₀H₁₆O₄S
Molecular Weight:361.503
Hs Code.:

Synonyms:

Suppliers and Price of ((3R,6R)-6-methylpiperidin-3-yl)methanol (1S)-(+)-10-camphorsulfonic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Bicyclo[2.2.1]heptane-1-methanesulfonicacid
1g
$ 1073.00

Alichem
((3R,6r)-6-methylpiperidin-3-yl)methanol
1g
$ 966.14

Total 4 raw suppliers

Chemical Property of ((3R,6R)-6-methylpiperidin-3-yl)methanol (1S)-(+)-10-camphorsulfonic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Bicyclo[2.2.1]heptane-1-methanesulfonicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ((3R,6R)-6-methylpiperidin-3-yl)methanol (1S)-(+)-10-camphorsulfonic acid

There total 2 articles about ((3R,6R)-6-methylpiperidin-3-yl)methanol (1S)-(+)-10-camphorsulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1088994-07-3
((3R)-6-methylpiperidin-3-yl)-methanol

: 3144-16-9,61380-66-3
(1S)-10-camphorsulfonic acid

: 1088994-09-5
((3R,6R)-6-methylpiperidin-3-yl)methanol (1S)-(+)-10-camphorsulfonic acid

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 1.75h; Large scale;
DOI:10.1021/op3002678

Reference yield: 47.0%

: 1088994-03-9
(6R)-methyl-6-methyl-2-oxopiperidine-3-carboxylate

: 3144-16-9,61380-66-3
(1S)-10-camphorsulfonic acid

: 1088994-09-5
((3R,6R)-6-methylpiperidin-3-yl)methanol (1S)-(+)-10-camphorsulfonic acid

Guidance literature:: (6R)-methyl-6-methyl-2-oxopiperidine-3-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; ethanol; at 0 - 20 ℃;

(1S)-10-camphorsulfonic acid; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1088994-09-5
((3R,6R)-6-methylpiperidin-3-yl)methanol (1S)-(+)-10-camphorsulfonic acid

: 1088994-41-5
(4-bromo-3-(((2R,5R)-5-(((5-fluoro-pyridin-2-yl)oxy)methyl)-2-methyl-piperidin-1-yl)carbonyl)phenyl)-methanol

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / dichloromethane / 3 h

2: pyridine / dichloromethane / 19 h / 0 - 20 °C

3: 1-methyl-pyrrolidin-2-one; caesium carbonate / 26 h / 60 °C

4: trifluoroacetic acid / dichloromethane / 3.5 h / -2 - 20 °C / Cooling with iso-propanol/ice bath

5: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine / N,N-dimethyl-formamide / 18 h / 22 °C

6: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 77 h / 20 - 85 °C

7: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 4 h / 20 °C

8: lithium borohydride / tetrahydrofuran / 0.5 h / 20 °C

With pyridine; 1-methyl-pyrrolidin-2-one; sodium periodate; osmium(VIII) oxide; lithium borohydride; potassium carbonate; benzotriazol-1-ol; caesium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;