N-[4-chloro-2-tert-butyldimethylsilyloxy-3-(N,N-dimethylaminosulfonyl)phenyl]-N'-(2-bromophenyl) thiourea

Base Information

Chemical Name:N-[4-chloro-2-tert-butyldimethylsilyloxy-3-(N,N-dimethylaminosulfonyl)phenyl]-N'-(2-bromophenyl) thiourea
CAS No.:364363-02-0
Molecular Formula:C₂₁H₂₉BrClN₃O₃S₂Si
Molecular Weight:579.054
Hs Code.:

Synonyms:N-[4-chloro-2-tert-butyldimethylsilyloxy-3-(N,N-dimethylaminosulfonyl)phenyl]-N'-(2-bromophenyl) thiourea

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Chemical Property of N-[4-chloro-2-tert-butyldimethylsilyloxy-3-(N,N-dimethylaminosulfonyl)phenyl]-N'-(2-bromophenyl) thiourea

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Technology Process of N-[4-chloro-2-tert-butyldimethylsilyloxy-3-(N,N-dimethylaminosulfonyl)phenyl]-N'-(2-bromophenyl) thiourea

There total 4 articles about N-[4-chloro-2-tert-butyldimethylsilyloxy-3-(N,N-dimethylaminosulfonyl)phenyl]-N'-(2-bromophenyl) thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 361393-21-7
N-[4-chloro-2-hydroxy-3-(N'',N''-dimethylaminosulfonyl)phenyl]-N'-(2-bromophenyl)-thiourea

: 18162-48-6
tert-butyldimethylsilyl chloride

: 364363-02-0
N-[4-chloro-2-tert-butyldimethylsilyloxy-3-(N,N-dimethylaminosulfonyl)phenyl]-N'-(2-bromophenyl) thiourea

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2006.08.042

Reference yield:

: 276702-25-1
3-amino-6-chloro-2-hydroxy-N,N-dimethylbenzenesulfonamide

: 364363-02-0
N-[4-chloro-2-tert-butyldimethylsilyloxy-3-(N,N-dimethylaminosulfonyl)phenyl]-N'-(2-bromophenyl) thiourea

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylformamide / 20 °C

2: imidazole / CH₂Cl₂ / 20 °C

With 1H-imidazole; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.08.042

Reference yield:

: 361392-60-1
2-tert-butyl-6-chloro-benzooxazole-7-sulfonyl chloride

: 364363-02-0
N-[4-chloro-2-tert-butyldimethylsilyloxy-3-(N,N-dimethylaminosulfonyl)phenyl]-N'-(2-bromophenyl) thiourea

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 20 °C

2: aq. H₂SO₄ / Heating

3: dimethylformamide / 20 °C

4: imidazole / CH₂Cl₂ / 20 °C

With 1H-imidazole; sulfuric acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.08.042